Back Cover: A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents (ChemMedChem 2/2013)

Authors

  • Dr. Haijun Chen,

    1. Chemical Biology Program, Department of Pharmacology & Toxicology, Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555 TX (USA)
    Search for more papers by this author
    • These authors contribute equally to this work.

  • Dr. Cheng Z. Wang,

    1. Chemical Biology Program, Department of Pharmacology & Toxicology, Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555 TX (USA)
    Search for more papers by this author
    • These authors contribute equally to this work.

  • Dr. Chunyong Ding,

    1. Chemical Biology Program, Department of Pharmacology & Toxicology, Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555 TX (USA)
    Search for more papers by this author
  • Christopher Wild,

    1. Chemical Biology Program, Department of Pharmacology & Toxicology, Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555 TX (USA)
    Search for more papers by this author
  • Dr. Bryan Copits,

    1. Molecular Pharmacology & Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, 60611 IL (USA)
    Search for more papers by this author
  • Prof. Geoffrey T. Swanson,

    1. Molecular Pharmacology & Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, 60611 IL (USA)
    Search for more papers by this author
  • Prof. Kenneth M. Johnson,

    1. Chemical Biology Program, Department of Pharmacology & Toxicology, Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555 TX (USA)
    Search for more papers by this author
  • Prof. Jia Zhou

    Corresponding author
    1. Chemical Biology Program, Department of Pharmacology & Toxicology, Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555 TX (USA)
    • Chemical Biology Program, Department of Pharmacology & Toxicology, Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555 TX (USA)
    Search for more papers by this author

Abstract

original image

The back cover picture shows the rational design of asymmetric bivalent positive allosteric modulators (PAMs) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor by using an effective, combined bio- and chemoinformatic approach. These ligands display marked potency in vitro and efficacy in vivo for preventing neuroapoptosis. For more details, see the Communication by Jia Zhou et al. on p. 226 ff.

Cartoon 1.

Ancillary