Mature HIV-1 capsid (CA) core is characterized by a fullerene cone-shaped structure made of hexamers and pentamers. Inhibition of its assembly is a novel mechanism through which to target HIV-1. The inside cover picture shows the characterization of potent CA assembly inhibitors (orange) as N-terminal domain (NTD) binders using 19F NMR and X-ray co-crystallography. For more details, see the Full Paper by Nathalie Goudreau, René Coulombe et al. on p. 405 ff.