Back Cover: Computational Studies Identifying Entry Inhibitor Scaffolds Targeting the Phe 43 Cavity of HIV-1 gp120 (ChemMedChem 3/2013)

Authors

  • Cristina Tintori,

    1. Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. De Gasperi 2, 53100 Siena (Italy)
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    • These authors contributed equally to this work.

  • Manikandan Selvaraj,

    1. Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. De Gasperi 2, 53100 Siena (Italy)
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    • These authors contributed equally to this work.

  • Dr. Roger Badia,

    1. IrsiCaixa, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona (Spain)
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  • Dr. Bonaventura Clotet,

    1. IrsiCaixa, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona (Spain)
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  • Dr. José A. Esté,

    1. IrsiCaixa, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916 Badalona (Spain)
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  • Prof. Maurizio Botta

    Corresponding author
    1. Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. De Gasperi 2, 53100 Siena (Italy)
    2. Biotechnology, College of Science and Technology, Temple University, Biolife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122 (USA)
    • Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. De Gasperi 2, 53100 Siena (Italy)
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Abstract

original image

The back cover picture shows the process of discovering small-molecule inhibitors of the gp120–CD4 protein[BOND]protein interaction by means of pharmacophore modeling and structure-based drug design. The screening campaign identified novel scaffolds for development of anti-HIV-1 agents. For more details, see the Full Paper by Maurizio Botta et al. on p. 475 ff.

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