SEARCH

SEARCH BY CITATION

Keywords:

  • aldehyde reductase;
  • aldose reductase;
  • benzothiadiazines;
  • inhibitors;
  • structure–activity relationships
Thumbnail image of graphical abstract

The inside cover picture shows a benzothiadiazine-1,1-dioxide inhibitor of aldose reductase (ALR2) bound in the active site. Structure–activity relationship studies led to inhibitors with enhanced activity and selectivity, highlighting the important role of the C7 side chain and providing insight into the pharmacophore requirements for ALR2 inhibition. For more details, see the Full Paper by Changjin Zhu et al. on p. 603 ff.