Inside Cover: Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation (ChemMedChem 5/2013)

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Abstract

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The inside cover picture shows a DNA-targeting artemisinin–netropsin drug conjugate docked into d(CGCGAATTCGCG) duplex DNA (PDB code: 1D86). The conjugate combines a trioxane warhead and a minor groove binder joined through a phenyl linker. For more details, see the Communication by Paul M. O'Neill et al. on p. 709 ff.

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