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Keywords:

  • aminoglycosides;
  • antibacterial activity;
  • antiprotozoal activity;
  • ribosomal decoding sites;
  • X-ray crystallography
Thumbnail image of graphical abstract

The back cover picture shows a sandfly, the insect carrying the parasite Leishmania donovani as a promastigote, which is responsible for parasitic infections in humans. The semi-synthetic 6′-hydroxysisomicin is shown bound to the A-site of the protozoal RNA, thus interfering with the protein synthesis machinery. For more details, see the Full Paper by Jiro Kondo, Stephen Hanessian et al. on p. 733 ff.