Back Cover: Crystal Structures of a Bioactive 6′-Hydroxy Variant of Sisomicin Bound to the Bacterial and Protozoal Ribosomal Decoding Sites (ChemMedChem 5/2013)

Authors

  • Dr. Jiro Kondo,

    Corresponding author
    1. Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo (Japan)
    • Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo (Japan)
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  • Mai Koganei,

    1. Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo (Japan)
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  • Juan Pablo Maianti,

    1. Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7 (Canada)
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  • Vu Linh Ly,

    1. Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7 (Canada)
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  • Prof. Stephen Hanessian

    Corresponding author
    1. Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7 (Canada)
    • Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7 (Canada)
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Abstract

original image

The back cover picture shows a sandfly, the insect carrying the parasite Leishmania donovani as a promastigote, which is responsible for parasitic infections in humans. The semi-synthetic 6′-hydroxysisomicin is shown bound to the A-site of the protozoal RNA, thus interfering with the protein synthesis machinery. For more details, see the Full Paper by Jiro Kondo, Stephen Hanessian et al. on p. 733 ff.

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