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Keywords:

  • antibiotics;
  • demethylvancomycin;
  • drug resistance;
  • structure–activity relationships;
  • synthesis design
Thumbnail image of graphical abstract

The inside cover picture shows the proposed binding mode of a demethylvancomycin analogue (white) with the peptidoglycan of vancomycin-resistant Enterococcus faecalis (teal), in which the NH–π interaction is predicted to compensate for the diminished binding affinity caused by the breaking of a conserved NH ⋅ ⋅ ⋅ O hydrogen bond in drug-resistant bacteria. For more details, see the Full Paper by Wen-Jiang Zhou, Xun Sun et al. on p. 976 ff.