Inside Cover: Design, Synthesis, and Antibacterial Activity of Demethylvancomycin Analogues against Drug-Resistant Bacteria (ChemMedChem 6/2013)

Authors

  • Dr. Jun Chang,

    1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)
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  • Si-Ji Zhang,

    1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)
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  • Yong-Wei Jiang,

    1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)
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  • Dr. Liang Xu,

    1. Department of Chemistry of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041 (China)
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  • Dr. Jian-Ming Yu,

    1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)
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  • Prof. Wen-Jiang Zhou,

    Corresponding author
    1. Animal Center, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)
    • Wen-Jiang Zhou, Animal Center, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)

      Xun Sun, Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)

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  • Prof. Dr. Xun Sun

    Corresponding author
    1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)
    • Wen-Jiang Zhou, Animal Center, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)

      Xun Sun, Department of Natural Products Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (China)

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Abstract

original image

The inside cover picture shows the proposed binding mode of a demethylvancomycin analogue (white) with the peptidoglycan of vancomycin-resistant Enterococcus faecalis (teal), in which the NH–π interaction is predicted to compensate for the diminished binding affinity caused by the breaking of a conserved NH ⋅ ⋅ ⋅ O hydrogen bond in drug-resistant bacteria. For more details, see the Full Paper by Wen-Jiang Zhou, Xun Sun et al. on p. 976 ff.

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