These authors contributed equally to this work.
Back Cover: Structure–Activity Relationships of Quinoxaline-Based 5-HT3A and 5-HT3AB Receptor-Selective Ligands (ChemMedChem 6/2013)
Version of Record online: 24 MAY 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 8, Issue 6, page 1020, June 2013
How to Cite
Thompson, A. J., Verheij, M. H. P., van Muijlwijk-Koezen, J. E., Lummis, S. C. R., Leurs, R. and de Esch, I. J. P. (2013), Back Cover: Structure–Activity Relationships of Quinoxaline-Based 5-HT3A and 5-HT3AB Receptor-Selective Ligands (ChemMedChem 6/2013). ChemMedChem, 8: 1020. doi: 10.1002/cmdc.201390024
- Issue online: 24 MAY 2013
- Version of Record online: 24 MAY 2013
- Cys loops;
- 5-HT3 receptors;
The back cover picture shows the extracellular domains of two of the five subunits that make up a 5-HT3 receptor. Quinoxalines (general structure shown) bind with reasonable potency to this receptor, probably at the orthosteric binding site located between two adjacent subunits. Through modifications to the functional groups at the R1, R2 and R3 positions, the ability of these ligands to distinguish between homomeric 5-HT3AR and heteromeric 5-HT3AB receptors was probed. For more details, see the Full Paper by Sarah C. R. Lummis et al. on p. 946 ff.