Inside Cover: A Parallel Semisynthetic Approach for Structure–Activity Relationship Studies of Peptide YY (ChemMedChem 9/2013)

Authors

  • Louise Albertsen,

    1. Department of Drug Design & Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen (Denmark)
    2. Department of Protein & Peptide Chemistry, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv (Denmark)
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  • Dr. Søren Østergaard,

    1. Department of Protein & Peptide Chemistry, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv (Denmark)
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  • Dr. Johan F. Paulsson,

    1. Department of Diabetes NBEs & Obesity Biology, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv (Denmark)
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  • Dr. Jens Chr. Norrild,

    Corresponding author
    1. Department of Protein & Peptide Chemistry, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv (Denmark)
    • Jens Chr. Norrild, Department of Protein & Peptide Chemistry, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv (Denmark)

      Kristian Strømgaard, Department of Drug Design & Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen (Denmark)

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  • Prof. Kristian Strømgaard

    Corresponding author
    1. Department of Drug Design & Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen (Denmark)
    • Jens Chr. Norrild, Department of Protein & Peptide Chemistry, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv (Denmark)

      Kristian Strømgaard, Department of Drug Design & Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen (Denmark)

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Abstract

original image

The inside cover picture shows a recombinant thioester fragment (pink tube) of the gut hormone peptide YY (PYY) used in a semisynthetic strategy for the design of C-terminally modified (blue chemical structure) PYY analogues with potential applications as antiobesity agents. Combining the native chemical ligation–desulfurization approach with a 96-well plate (background) format allowed rapid parallel generation of PYY analogues that were subsequently tested in cell-based GPCR (blue cartoon) assays. For more details, see the Full Paper by Jens Chr. Norrild, Kristian Strømgaard et al. on p. 1505 ff.

Cartoon 1.

Ancillary