Back Cover: Glucosylceramide Mimics: Highly Potent GCase Inhibitors and Selective Pharmacological Chaperones for Mutations Associated with Types 1 and 2 Gaucher Disease (ChemMedChem 11/2013)

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Abstract

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The back cover picture shows the structure of glucocerebrosidase in complex with its substrate, glucosylceramide (GlcCer), and the structure of an iminoglycolipid acting as a mimic of GlcCer. This compound is a very potent inhibitor of glucocerebrosidase and exhibits significant chaperone effect on the N370S and L444P mutations, which are responsible for type 1 and type 2 Gaucher disease, respectively. For more details, see the Full Paper by Olivier R. Martin et al. on p. 1805 ff.

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