2-Aminopyridine Derivatives as Potential σ2 Receptor Antagonists (pages 1847–1857)
Dr. Carmen Abate, Prof. Savina Ferorelli, Dr. Mauro Niso, Dr. Cesarea Lovicario, Dr. Vittoria Infantino, Dr. Paolo Convertini, Prof. Dr. Roberto Perrone and Prof. Dr. Francesco Berardi
Article first published online: 13 AUG 2012 | DOI: 10.1002/cmdc.201200246
A reduced fat option: N-Cyclohexylpiperazine derivatives linked to a 2-aminopyridine moiety were generated as less lipophilic analogues of the σ2 agonist PB28. The new N-cyclohexylpiperazines, which display high affinity for σ subtypes, are devoid of antiproliferative activity and may be proposed as σ2 receptor antagonists.