Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor (pages 209–212)
Dr. Chien-Huang Wu, Dr. Chun-Ping Chang, Dr. Jen-Shin Song, Jiing-Jyh Jan, Ming-Chen Chou, Szu-Huei Wu, Kai-Chia Yeh, Dr. Ying-Chieh Wong, Chieh-Jui Hsieh, Dr. Chiung-Tong Chen, Tzu-Ting Kao, Dr. Su-Ying Wu, Ching-Fang Yeh, Dr. Chen-Tso Tseng, Dr. Yu-Sheng Chao and Dr. Kak-Shan Shia
Version of Record online: 20 DEC 2011 | DOI: 10.1002/cmdc.201100525
Going mobile: Based on screening hit 1, a novel class of polyamine compounds, as represented by compound 8, were identified as potent and selective CXCR4 antagonists. CXCR4-targeted molecules, as demonstrated by the marketed AMD3100 and 8, are able to mobilize stem cells from bone marrow effectively and are expected to have broad utility in cell therapy and regenerative medicine.