Synthesis of Gd and 68Ga Complexes in Conjugation with a Conformationally Optimized RGD Sequence as Potential MRI and PET Tumor-Imaging Probes (pages 1084–1093)
Dr. Leonardo Manzoni, Dr. Laura Belvisi, Dr. Daniela Arosio, Dr. Maria Paola Bartolomeo, Dr. Aldo Bianchi, Dr. Chiara Brioschi, Dr. Federica Buonsanti, Dr. Claudia Cabella, Prof. Cesare Casagrande, Dr. Monica Civera, Dr. Marilenia De Matteo, Dr. Lorenza Fugazza, Dr. Luciano Lattuada, Dr. Federico Maisano, Luigi Miragoli, Dr. Cristina Neira, Dr. Michael Pilkington-Miksa and Prof. Carlo Scolastico
Article first published online: 5 APR 2012 | DOI: 10.1002/cmdc.201200043
Persistence pays: Novel Gd and 68Ga chelates conjugated with a cyclic RGD peptidomimetic integrin ligand were prepared. Preliminary in vivo evaluation of the first integrin-targeted AAZTA(68Ga) complex showed good uptake and persistence in a xenograft mouse model of human glioblastoma (U-87 MG) cells.