Hyla Allouche-Arnon and Trevor Wade contributed equally.
In vivo magnetic resonance imaging of glucose – initial experience
Article first published online: 29 OCT 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Contrast Media & Molecular Imaging
Volume 8, Issue 1, pages 72–82, January/February 2013
How to Cite
Allouche-Arnon, H., Wade, T., Waldner, L. F., Miller, V. N., Gomori, J. M., Katz-Brull, R. and McKenzie, C. A. (2013), In vivo magnetic resonance imaging of glucose – initial experience. Contrast Media Mol Imaging, 8: 72–82. doi: 10.1002/cmmi.1497
Rachel Katz-Brull and Charles A. McKenzie contributed equally.
- Issue published online: 29 OCT 2012
- Article first published online: 29 OCT 2012
- Manuscript Accepted: 27 JUL 2012
- Manuscript Revised: 16 JUL 2012
- Manuscript Received: 16 OCT 2011
- Canada Research Chairs program (C.A.M.), the Ontario Research Fund (C.A.M.), and the Israel Science Foundation. Grant Number: grant no. 284/10 to R.K.B.
- 3 T;
A new noninvasive, nonradioactive approach for glucose imaging using spin hyperpolarization technology and stable isotope labeling is presented. A glucose analog labeled with 13C at all six positions increased the overall hyperpolarized imaging signal; deuteration at all seven directly bonded proton positions prolonged the spin–lattice relaxation time. High-bandwidth 13C imaging overcame the large glucose carbon chemical shift dispersion. Hyperpolarized glucose images in the live rat showed time-dependent organ distribution patterns. At 8 s after the start of bolus injection, the inferior vena cava was demonstrated at angiographic quality. Distribution of hyperpolarized glucose in the kidneys, vasculature, and heart was demonstrated at 12 and 20 s. The heart-to-vasculature intensity ratio at 20 s suggests myocardial uptake. Cancer imaging, currently performed with 18 F-deoxyglucose positron emission tomography (FDG-PET), warrants further investigation, and glucose imaging could be useful in a vast range of clinical conditions and research fields where the radiation associated with the FDG-PET examination limits its use. Copyright © 2012 John Wiley & Sons, Ltd.