These authors contributed equally.
A DOTAM-based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity
Article first published online: 4 FEB 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Contrast Media & Molecular Imaging
Volume 8, Issue 3, pages 289–292, May/June 2013
How to Cite
Stevens, T. K., Milne, M., Elmehriki, A. A. H., Suchý, M., Bartha, R. and Hudson, R. H. E. (2013), A DOTAM-based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity. Contrast Media Mol Imaging, 8: 289–292. doi: 10.1002/cmmi.1527
- Issue published online: 11 JAN 2013
- Article first published online: 4 FEB 2013
- Manuscript Accepted: 11 DEC 2012
- Manuscript Revised: 6 NOV 2012
- Manuscript Received: 10 AUG 2012
- t-butyl amide
The Tm3+ chelate of DOTAM [1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane] possessing sterically demanding t-butyl amide substitution favors TSAP geometry. This chelate displayed a paraCEST signal associated with the highly shifted amide proton signal at approximately −100 ppm that was beyond the frequency of macromolecule magnetization transfer. This signal also displayed high temperature dependence (0.57 ppm °C−1) in the range of 35–42 °C and at neutral pH. Copyright © 2013 John Wiley & Sons, Ltd.