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Keywords:

  • PARACEST;
  • MRI;
  • temperature;
  • TSAP;
  • SAP;
  • thulium;
  • t-butyl amide

The Tm3+ chelate of DOTAM [1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane] possessing sterically demanding t-butyl amide substitution favors TSAP geometry. This chelate displayed a paraCEST signal associated with the highly shifted amide proton signal at approximately −100 ppm that was beyond the frequency of macromolecule magnetization transfer. This signal also displayed high temperature dependence (0.57 ppm °C−1) in the range of 35–42 °C and at neutral pH. Copyright © 2013 John Wiley & Sons, Ltd.