68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals
Version of Record online: 31 MAR 2008
Copyright © 2008 John Wiley & Sons, Ltd.
Contrast Media & Molecular Imaging
Volume 3, Issue 2, pages 53–63, March/April 2008
How to Cite
Fani, M., André, J. P. and Maecke, H. R. (2008), 68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals. Contrast Media Mol Imaging, 3: 53–63. doi: 10.1002/cmmi.232
- Issue online: 15 APR 2008
- Version of Record online: 31 MAR 2008
- Manuscript Accepted: 20 FEB 2008
- Manuscript Revised: 12 FEB 2008
- Manuscript Received: 8 NOV 2007
- nuclear probes;
PET (positron emission tomography) is a powerful diagnostic and imaging technique which requires short-lived positron emitting isotopes. The most commonly used are accelerator-produced 11C and 18F. An alternative is the use of metallic positron emitters. Among them 68Ga deserves special attention because of its availability from long-lived 68Ge/68Ga generator systems which render 68Ga radiopharmacy independent of an onsite cyclotron. The coordination chemistry of Ga3+ is dominated by its hard acid character. A variety of mono- and bifunctional chelators have been developed which allow the formation of stable 68Ga3+complexes and convenient coupling to biomolecules. 68Ga coupling to small biomolecules is potentially an alternative to 18F- and 11C-based radiopharmacy. In particular, peptides targeting G-protein coupled receptors overexpressed on human tumour cells have shown preclinically and clinically high and specific tumour uptake. Kit-formulated precursors along with the generator may be provided, similar to the 99Mo/99mTc-based radiopharmacy, still the mainstay of nuclear medicine. Copyright © 2008 John Wiley & Sons, Ltd.