Imaging efficiency of an X-ray contrast agent-incorporated polymeric microparticle

Authors

  • Sungsook Ahn,

    1. Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, Korea
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  • Sung Yong Jung,

    1. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Korea
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  • Jin Pyung Lee,

    1. School of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang, Korea
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  • Sang Joon Lee

    Corresponding author
    1. Center for Biofluid and Biomimic Research, Pohang University of Science and Technology, Pohang, Korea
    2. School of Environmental Science and Engineering, Pohang University of Science and Technology, Pohang, Korea
    3. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea
    • Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Korea
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S. J. Lee, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang 790-784, Korea.

E-mail: sjlee@postech.ac.kr

Abstract

Biocompatible polymeric encapsulants have been widely used as a delivery vehicle for a variety of drugs and imaging agents. In this study, X-ray contrast agent (iopamidol) is encapsulated into a polymeric microparticle (polyvinyl alcohol) as a particulate flow tracer in synchrotron X-ray imaging system. The physical properties of the designed microparticles are investigated and correlated with enhancement in the imaging efficiency by experimental observation and theoretical interpretation. The X-ray absorption ability of the designed microparticle is assessed by Beer–Lambert–Bouguer law. Particle size, either in dried state or in solvent, primarily dominates the X-ray absorption ability under the given condition, thus affecting imaging efficiency of the designed X-ray contrast flow tracers. Copyright © 2011 John Wiley & Sons, Ltd.

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