This article is published in Contrast Media and Molecular Imaging as part of the special issue on Photoacoustic Imaging, edited by Dr. Gregory Lanza, Department of Medicine, Washington University Medical Hospital.
Photoacoustic tomography: fundamentals, advances and prospects
Article first published online: 25 OCT 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Contrast Media & Molecular Imaging
Special Issue: Photoacoustic Imaging
Volume 6, Issue 5, pages 332–345, September/October 2011
How to Cite
Yao, J. and Wang, L. V. (2011), Photoacoustic tomography: fundamentals, advances and prospects. Contrast Media Mol Imaging, 6: 332–345. doi: 10.1002/cmmi.443
- Issue published online: 25 OCT 2011
- Article first published online: 25 OCT 2011
- Manuscript Revised: 16 FEB 2011
- Manuscript Accepted: 16 FEB 2011
- Manuscript Received: 14 DEC 2010
- National Institutes of Health. Grant Numbers: R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, 5P60 DK02057933
- photoacoustic tomography;
- photoacoustic microscopy;
- photoacoustic computed tomography;
- photoacoustic endoscopy;
- multiscale imaging;
- optical absorption contrast
Optical microscopy has been contributing to the development of life science for more than three centuries. However, due to strong optical scattering in tissue, its in vivo imaging ability has been restricted to studies at superficial depths. Advances in photoacoustic tomography (PAT) now allow multiscale imaging at depths from sub-millimeter to several centimeters, with spatial resolutions from sub-micrometer to sub-millimeter. Because of this high scalability and its unique optical absorption contrast, PAT is capable of performing anatomical, functional, molecular and fluid-dynamic imaging at various system levels, and is playing an increasingly important role in fundamental biological research and clinical practice. This review discusses recent technical progress in PAT and presents corresponding applications. It ends with a discussion of several prospects and their technical challenges. Copyright © 2011 John Wiley & Sons, Ltd.