Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use
Article first published online: 30 JAN 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Contrast Media & Molecular Imaging
Volume 7, Issue 1, pages 1–6, January/February 2012
How to Cite
Skotland, T. (2012), Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use. Contrast Media Mol Imaging, 7: 1–6. doi: 10.1002/cmmi.458
- Issue published online: 30 JAN 2012
- Article first published online: 30 JAN 2012
- Manuscript Accepted: 16 MAY 2011
- Manuscript Revised: 11 APR 2011
- Manuscript Received: 10 NOV 2010
- molecular imaging;
- intracellular targets;
Molecular imaging (MI) takes advantage of several new techniques to detect biomarkers or biochemical and cellular processes, with the goal of obtaining high sensitivity, specificity and signal-to-noise ratio imaging of disease. The imaging modalities bearing the most promise for MI are positron emission tomography (PET), single photon emission computer tomography (SPECT) and different optical imaging techniques with high sensitivity. Also magnetic resonance imaging (MRI) with contrast agents like ultra-small superparamagnetic iron oxide particles (USPIO), magnetic resonance spectroscopy and ultrasound imaging with contrast agents may be useful approaches. MI techniques have been used in the clinic for many years, i.e. PET imaging using 18 F-labeled fluorodeoxyglucose. Animal studies have during the last years revealed great potential for MI also with several other agents. The focus of the present article is the challenges of clinical imaging of intracellular targets following intravenous injection of the agents. Thus, the great challenge of getting enough contrast agent into the cytosol and at the same time obtaining a low signal from tissue just outside the diseased area is discussed. Copyright © 2012 John Wiley & Sons, Ltd.