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1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging

Authors

  • Yan Yang,

    1. A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School 149, Charlestown, MA, USA
    2. Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China
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    • Both authors contributed equally to this work.

  • Daniel T. Schühle,

    1. A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School 149, Charlestown, MA, USA
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    • Both authors contributed equally to this work.

  • Guangping Dai,

    1. A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School 149, Charlestown, MA, USA
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  • Jamu K. Alford,

    1. A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School 149, Charlestown, MA, USA
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  • Peter Caravan

    Corresponding author
    1. A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School 149, Charlestown, MA, USA
    • P. Caravan, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA. E-mail: caravan@nmr.mgh.harvard.edu

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ABSTRACT

Proton-based chemical shift imaging probes were encapsulated inside nano-carriers to increase the sensivitity of the reporters. Co-encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection. Copyright © 2011 John Wiley & Sons, Ltd.

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