Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

September/October 2006

Volume 1, Issue 5

Pages 183–228

  1. Editorials

    1. Top of page
    2. Editorials
    3. How To…
    4. Full Papers
    5. Current Awareness
    1. The «How to…»: a new type of paper! (page 183)

      Proffessor Silvio Aime and Proffessor Robert N. Muller

      Version of Record online: 10 OCT 2006 | DOI: 10.1002/cmmi.109

  2. How To…

    1. Top of page
    2. Editorials
    3. How To…
    4. Full Papers
    5. Current Awareness
    1. How to determine free Gd and free ligand in solution of Gd chelates. A technical note (pages 184–188)

      Alessandro Barge, Giancarlo Cravotto, Eliana Gianolio and Franco Fedeli

      Version of Record online: 28 SEP 2006 | DOI: 10.1002/cmmi.110

      Thumbnail image of graphical abstract

      Free ligand and free Gd3+ ions are both highly toxic to living systems. Free Gd3+ ions may have a profound effect on the contrast in the MR image. Therefore any Gd complex preparation has to be carefully checked for the content of free ligand and free metal ions. Herein the currently used procedures that allow to assess the amounts of free metal ions and free ligand in a solution of a given Gd complex are described in detail.

  3. Full Papers

    1. Top of page
    2. Editorials
    3. How To…
    4. Full Papers
    5. Current Awareness
    1. A new type of susceptibility-artefact-based magnetic resonance angiography: intra-arterial injection of superparamagnetic iron oxide particles (SPIO) A Resovist® in combination with TrueFisp imaging: a feasibility study (pages 189–195)

      Robbert M. Maes, Jonathan S. Lewin, Jeffrey L. Duerk, Bernd Misselwitz, Cunera J. M. Kiewiet and Frank K. Wacker

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cmmi.105

      Thumbnail image of graphical abstract

      The intraarterial injection of diluted Super Paramagnetic Particles of Iron Oxide (SPIO)of 10 mmol Fe/l in an animal model temporary changes the intraluminal field strength during Magnetic Resonance Angiography (MRA) and results in dark blood images, which is potentially useful during interventional imaging.

    2. An HPLC/mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: prostate-specific membrane antigen small molecule derivatives (pages 196–211)

      Valerie Humblet, Preeti Misra and John V. Frangioni

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cmmi.106

      Thumbnail image of graphical abstract

      Many disease-specific, small molecule targeting ligands exhibit high charge and/or hydrophobicity. We describe a general-purpose HPL/mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics derived from such ligands. Using highly anionic small molecules specific for prostate-specific membrane antigen as examples, we demonstrate that agents prepared using this platform target living human prostate cancer cells with high affinity and specificity.

    3. L-Amino acid load to enhance PET differentiation between tumor and inflammation: an in vitro study on 18F-FET uptake (pages 212–220)

      S. Laïque, D. Egrise, M. Monclus, F. Schmitz, C. Garcia, C. Lemaire, A. Luxen and S. Goldman

      Version of Record online: 28 SEP 2006 | DOI: 10.1002/cmmi.107

      Thumbnail image of graphical abstract

      Cellular uptake of FET was studied on rat osteosarcoma cells (ROS 17/2.8) and human leukocytes, initially loaded with non radioactive L-tyrosine, in order to measure potential effects of AA content on the distinction between tumor and inflammatory lesions. ROS 17/2.8 showed a higher sensitivity to preload effects on FET uptake than the leukocytes, which suggests that preload with L-tyrosine, prior to the administration of FET, may be a potential procedure to improve PET differentiation between tumor and inflammation.

  4. Current Awareness

    1. Top of page
    2. Editorials
    3. How To…
    4. Full Papers
    5. Current Awareness

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