Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

November/December 2006

Volume 1, Issue 6

Pages 229–298

  1. Editorials

    1. Top of page
    2. Editorials
    3. Review Articles
    4. Full Papers
    5. Current Awareness
    1. Editorial (page 229)

      Silvio Aime and Robert N. Muller

      Version of Record online: 8 DEC 2006 | DOI: 10.1002/cmmi.118

  2. Review Articles

    1. Top of page
    2. Editorials
    3. Review Articles
    4. Full Papers
    5. Current Awareness
    1. Imaging of the lymphatic system: new horizons (pages 230–245)

      Tristan Barrett, Peter L. Choyke and Hisataka Kobayashi

      Version of Record online: 8 DEC 2006 | DOI: 10.1002/cmmi.116

      Thumbnail image of graphical abstract

      The lymphatic system is difficult to evaluate by imaging because its channels and lymph nodes are small and not directly accessible. At present the respective role each modality plays remains to be determined. The field of lymphatic imaging is ever evolving, and technological advances, combined with the development of new contrast agents, continue to improve diagnostic accuracy.

  3. Full Papers

    1. Top of page
    2. Editorials
    3. Review Articles
    4. Full Papers
    5. Current Awareness
    1. Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepatic asyaloglycoprotein receptor: cell internalization and animal imaging studies (pages 246–258)

      M. I. M. Prata, A. C. Santos, S. Torres, J. P. André, J. A. Martins, M. Neves, M. L. García-Martín, T. B. Rodrigues, P. López-Larrubia, S. Cerdán and C. F. G. C. Geraldes

      Version of Record online: 19 OCT 2006 | DOI: 10.1002/cmmi.111

      Thumbnail image of graphical abstract

      Radiolabeled [153Sm]3+-DOTA-amide dendrimeric thioglycoconjugates with terminal galactosyl groups (eg. 153SmDOTAGal2) efficiently enter hepatoma cells in vitro (gamma activity cell studies) and Wistar rat liver in vivo (biodistribution, gamma-imaging and pharmacokinetics) via the asialoglycoprotein receptor mediated endocytosis, a process blocked by asialofetuin. However, the DCE-MRI assessment of the corresponding Gd3+ chelates shows liver-to-kidney contrast effects not significantly better than those shown by GdDTPA. The quick wash-out of these hydrophilic complexes from the liver may prevent their sufficient concentration within the hepatocytes.

    2. Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow (pages 259–266)

      A. L. Klibanov, J. J. Rychak, W. C. Yang, S. Alikhani, B. Li, S. Acton, J. R. Lindner, K. Ley and S. Kaul

      Version of Record online: 22 NOV 2006 | DOI: 10.1002/cmmi.113

      Thumbnail image of graphical abstract

      Ultrasound contrast microbubbles were decorated with biotinylated polyacrylamide sialyl Lewisx (PSLex) via streptavidin coupling. P-selectin targeting of PSLex-bubbles and anti-P-selectin antibody-bubbles was compared in the parallel plate flow chamber; at high shear flow, targeting of PSLex-carrying bubbles was consistently superior. In the inflamed murine femoral artery setting, PSLex-mediated microbubble targeting was superior to antibody-mediated targeting; in femoral vein, PSLex and antibody-mediated microbubble targeting were comparable.

    3. Pharmacokinetic and in vivo evaluation of a self-assembled gadolinium(III)-iron(II) contrast agent with high relaxivity (pages 267–278)

      Tatjana N. Parac-Vogt, Luce Vander Elst, Kristof Kimpe, Sophie Laurent, Carmen Burtéa, Feng Chen, Rik Van Deun, Yicheng Ni, Robert N. Muller and Koen Binnemans

      Version of Record online: 17 NOV 2006 | DOI: 10.1002/cmmi.114

      Thumbnail image of graphical abstract

      A tetrametallic supramolecular complex [(Ln-DTPA-phen)3Fe] (Ln [DOUBLE BOND] Gd, Eu, La) has been obtained upon self-assembly around one iron(II) ion of three 1,10-phenantroline-based molecules substituted in 5′-position with the poly-aminocarboxylate diethylenetriamine-N,N,N′,N″,N″-pentaacetate, DTPA-phen4−. MRI-histomorphological correlation studies of [Gd-DTPA-phen] and [(Gd-DTPA-phen)3Fe] showed that both agents displayed potent contrast enhancement. The necrosis avidity tests indicated that the supramolecular complex [(Gd-DTPA-phen)3Fe] exhibits necrosis avidity.

    4. Characterization of the in vitro adherence behavior of ultrasound responsive double-shelled microspheres targeted to cellular adhesion molecules (pages 279–290)

      Susanne Ottoboni, Robert E. Short, Matthew B. Kerby, E. Glenn Tickner, Erica Steadman and Thomas B. Ottoboni

      Version of Record online: 4 DEC 2006 | DOI: 10.1002/cmmi.115

      Thumbnail image of graphical abstract

      Novel adhesion molecule-targeted double-shelled microspheres which encapsulate nitrogen gas were tested for target-specific adherence to ICAM-1 and VCAM-1 surfaces in vitro. Under static and flow conditions, adherence as a function of target and ligand density was found to be ligand dependent, and the mean diameter of adhered microspheres decreased with increasing shear at low target/ligand densities. Adhered microspheres were readily detected using ultrasound.

  4. Current Awareness

    1. Top of page
    2. Editorials
    3. Review Articles
    4. Full Papers
    5. Current Awareness

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