Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

March/April 2007

Volume 2, Issue 2

Pages 67–111

  1. How To …

    1. Top of page
    2. How To …
    3. Full Papers
    4. Current Awareness
    5. Errata
    1. How to determine the number of inner-sphere water molecules in Lanthanide(III) complexes by 17O NMR spectroscopy. A technical note (pages 67–71)

      Kristina Djanashvili and Joop. A. Peters

      Article first published online: 24 APR 2007 | DOI: 10.1002/cmmi.132

      Thumbnail image of graphical abstract

      The number of coordinated water molecules in Ln(III)-complexes (q) is a determinative factor for the relaxation process. Ln(III)-induced 17O NMR water shifts can be used for determination of this parameter due to the exchange of bulk water with the inner-sphere water molecules. Herein we discuss some practical aspects of this method and give a detailed example of a typical data processing.

  2. Full Papers

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    4. Current Awareness
    5. Errata
    1. MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent (pages 72–81)

      Olaf Saborowski, Gerhard H. Simon, Hans-Juergen Raatschen, Michael F. Wendland, Yanjun Fu, Tobias Henning, Rick Baehner, Claire Corot, Mei-Hsiu Chen and Heike E. Daldrup-Link

      Article first published online: 27 MAR 2007 | DOI: 10.1002/cmmi.128

      Thumbnail image of graphical abstract

      We investigated, whether the folate-receptor (FR) specific Gd-chelate P866 may target immune-mediated arthritis in a rat model. MR imaging was obtained before and after injection of P866, the non-FR-targeted P866-analogue P1001 and Gd-DOTA. P866, but not P1001 or Gd-DOTA, provided a prolonged T1-enhancement of the synovitis. Histopathology confirmed the presence of FR in inflamed joints, but not normal joints.

    2. Spectral near-infrared fluorescence imaging of curved surfaces using projection reconstruction algorithms (pages 82–87)

      Yukihiro Hama, Yoshinori Koyama, Marcelino Bernardo, Peter L. Choyke and Hisataka Kobayashi

      Article first published online: 24 APR 2007 | DOI: 10.1002/cmmi.129

      Thumbnail image of graphical abstract

      Defocus created by blurring from the curved surface has been an obstacle to creating anatomically interpretable surface images. We present a deblurring methodology during spectral near-infrared fluorescence imaging using signal intensity projection algorithms. The minimum and the median intensity projection images demonstrated the better deblurring in a lymphatic phantom, whereas with in vivo imaging the median intensity projection images more clearly visualized the entire lymphatics than the other projection techniques.

    3. In-vivo high-resolution X-ray microtomography for liver and spleen tumor assessment in mice (pages 88–93)

      M. Almajdub, M. Nejjari, G. Poncet, L. Magnier, E. Chereul, C. Roche and M. Janier

      Article first published online: 20 APR 2007 | DOI: 10.1002/cmmi.130

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      The present study sought to validate the use of a specific contrast agent (DHOG) with high-resolution X-ray microtomography for the evaluation of liver and spleen tumors in mice. Signal intensity dramatically increased in normal spleen and liver, while no uptake was observed in the respective tumors. Spleen and tumor segmentation was easily obtained. The smallest liver metastasis detected measured 0.3 mm in diameter. Furthermore, it was possible to observe an increased signal in the liver and spleen 15 days after injection of DHOG. This finding may facilitate follow-up of the tumor growth.

    4. The effects of intramolecular H-bond formation on the stability constant and water exchange rate of the Gd(III)-diethylenetriamine-N′-(3-amino-1,1-propylenephosphonic)-N, N,N″,N″-tetraacetate complex (pages 94–102)

      Zsolt Baranyai, Eliana Gianolio, Kondareddiar Ramalingam, Rolf Swenson, Ramachandran Ranganathan, E. Brücher and Silvio Aime

      Article first published online: 24 APR 2007 | DOI: 10.1002/cmmi.131

      Thumbnail image of graphical abstract

      To mimic intermolecular H-bonding interactions with biological macromolecules, the lanthanide(III) complexes of DTPA-monophosphonate ligand bearing a propylamino moiety were synthesized. Their thermodynamic stabilities and the exchange lifetime of the coordinated water were compared with those of the analog complexes with DTPA and the parent DTPA-monophosphonate derivative. It was found that the intramolecular H-bond between the propylamino group and the phosphonate moiety in NP-DTPA complexes causes displacements of electric charges, affecting the properties of the coordination cage.

  3. Current Awareness

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    2. How To …
    3. Full Papers
    4. Current Awareness
    5. Errata
    1. You have free access to this content
  4. Errata

    1. Top of page
    2. How To …
    3. Full Papers
    4. Current Awareness
    5. Errata
    1. You have free access to this content
      Erratum: MR imaging in assessing cardiovascular interventions and myocardial injury (page 111)

      Alexis Jacquier, Charles B Higgins and Maythem Saeed

      Article first published online: 2 MAY 2007 | DOI: 10.1002/cmmi.133

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