MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent (pages 72–81)
Olaf Saborowski, Gerhard H. Simon, Hans-Juergen Raatschen, Michael F. Wendland, Yanjun Fu, Tobias Henning, Rick Baehner, Claire Corot, Mei-Hsiu Chen and Heike E. Daldrup-Link
Article first published online: 27 MAR 2007 | DOI: 10.1002/cmmi.128
We investigated, whether the folate-receptor (FR) specific Gd-chelate P866 may target immune-mediated arthritis in a rat model. MR imaging was obtained before and after injection of P866, the non-FR-targeted P866-analogue P1001 and Gd-DOTA. P866, but not P1001 or Gd-DOTA, provided a prolonged T1-enhancement of the synovitis. Histopathology confirmed the presence of FR in inflamed joints, but not normal joints.