Dual-modality in vivo monitoring of subventricular zone stem cell migration and metabolism (pages 130–138)
Francesca Cicchetti, Robert E. Gross, Jeff W.M. Bulte, Mary Owen, Iris Chen, Martine Saint-Pierre, Xukui Wang, Meixiang Yu and Anna-Liisa Brownell
Article first published online: 22 JUN 2007 | DOI: 10.1002/cmmi.138
MRI studies showed minimal trafficking of the rat subventricular zone stem cells labeled with superparamagnetic iron oxide particles after transplantation into the rat striatum, while after transplantation into the rostral migratory stream (RMS) they migrated into the olfactory bulb. PET studies showed stem cell transplantation induced functional enhancement in the host after striatal transplantation and minor changes after RMS transplantation. Taken together, these studies demonstrate the importance of in vivo imaging studies to investigate fate and function of transplanted stem cells.