Improved fluorescence of indocyanine green in vitro and in vivo after simple cooling procedures (pages 191–197)
Sophie Boddington, Elizabeth J. Sutton, Ella Jones, Derk D. Purcell, Tobias D. Henning, Sidhartha Tavri, Reinhard Meier, Akhilesh Sista, Yanjun Fu and Heike Daldrup-Link
Version of Record online: 30 OCT 2008 | DOI: 10.1002/cmmi.251
Polymer-coated cobalt nanoparticles were synthesized and their magnetic resonance relaxivities measured at a range of temperatures and two magnetic field strengths of 1.5 and 3 T. From the measured relaxation rates R1 and R2, the relaxivities r1 and r2 can be derived with the highest values obtained at 1.5 T of 7.4 and 88 mM−1 s−1, respectively. These values are similar to those reported for iron oxide with larger core size, demonstrating the potential use of cobalt nanoparticles as negative contrast agents.