Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

November/December 2008

Volume 3, Issue 6

Pages 215–261

  1. Full Papers

    1. Top of page
    2. Full Papers
    3. Errata
    4. Current Awareness
    1. A new method for the aqueous functionalization of superparamagnetic Fe2O3 nanoparticles (pages 215–222)

      Fernando Herranz, Mª. Puerto Morales, Alejandro G. Roca, Ramón Vilar and Jesús Ruiz-Cabello

      Article first published online: 12 DEC 2008 | DOI: 10.1002/cmmi.254

      Thumbnail image of graphical abstract

      A new method has been developed for the synthesis of hydrophilic superparamagnetic nanoparticles. By means of an easy experimental set up particles of different sizes can be obtained. This new method shows a high control over size, size distribution and surface composition. The particles have been covalently functionalised through amide formation in water with different molecules. With this approach iron oxide nanoparticles stable in water can be prepared and used as contrast agents for MRI and for molecular imaging.

    2. Magnetic labeling of non-phagocytic adherent cells with iron oxide nanoparticles: a comprehensive study (pages 223–232)

      Sébastien Boutry, Stéphanie Brunin, Isabelle Mahieu, Sophie Laurent, Luce Vander Elst and Robert N. Muller

      Article first published online: 12 DEC 2008 | DOI: 10.1002/cmmi.256

      Thumbnail image of graphical abstract

      Several types of small particles of iron oxide (SPIO, 65-150 nm Ø) or ultrasmall particles of iron oxide (USPIO, 20-40 nm Ø) were used to magnetically label non-phagocytic adherent cells in culture. By T2-weighted MRI and Prussian blue iron staining, it was found that a larger size (SPIO vs USPIO) and a non-neutral surface coating (carboxydextran vs dextran) significantly increased the cell tagging efficiency of iron oxide nanoparticles. The relative concentration of magnetic tag/cells in culture also appeared to be important.

    3. Incorporation of an apoE-derived lipopeptide in high-density lipoprotein MRI contrast agents for enhanced imaging of macrophages in atherosclerosis (pages 233–242)

      Wei Chen, Esad Vucic, Eik Leupold, Willem J. M. Mulder, David P. Cormode, Karen C. Briley-Saebo, Alessandra Barazza, Edward A. Fisher, Margitta Dathe and Zahi A. Fayad

      Article first published online: 12 DEC 2008 | DOI: 10.1002/cmmi.257

      Thumbnail image of graphical abstract

      We incorporated a carboxyfluoresceine-labeled apolipoprotein E-derived lipopeptide, P2fA2, into reconstituted high-density lipoprotein (rHDL-P2A2) as Gd-based magnetic resonance (MR) contrast agent. These nanoparticles had enhanced delivery efficiency to murine macrophages in vitro and had higher efficacy than rHDL nanoparticles for in vivo detection of macrophages in atherosclerotic plaques using high-resolution MR in the apoE-/- mouse model of atherosclerosis.

    4. New synthesis of a high molecular weight ligand derived from dota; thermodynamic stability of the MRI contrast agent formed with gadolinium (pages 243–252)

      Jean-Claude Pierrard, Jean Rimbault, Michel Aplincourt, Soizic Le Greneur and Marc Port

      Article first published online: 12 DEC 2008 | DOI: 10.1002/cmmi.258

      Thumbnail image of graphical abstract

      The new total synthesis in four steps of the compound P1041, a high molecular mass ligand (MW 6.32 kDa) derived from dota, is reported. Study of the systems P1041/Na+ and P1041/Gd3+ led to the determination of the stability constants corresponding to the species Na(P1041)Hh (h = 0, 2 or 4) and to the complexes Gd(P1041)Hh (h = 0, 2, 3, 4 or 5). The complexing ability of P1041 towards Gd3+ is compared with those of dota and tetracarboxylated dota. At physiological pH = 7.4, the very stable species Gd(P1041)H4 of this rapid clearance blood pool agent is predominant.

  2. Errata

    1. Top of page
    2. Full Papers
    3. Errata
    4. Current Awareness
    1. You have free access to this content
      Erratum: Identification of residual ischemia, infarction, and microvascular impairment in revascularized myocardial infarction using 64-slice MDCT (page 253)

      Andre D. Furtado, Marcus Carlsson, Max Wintermark, Karen Ordovas and Maythem Saeed

      Article first published online: 12 DEC 2008 | DOI: 10.1002/cmmi.263

  3. Current Awareness

    1. Top of page
    2. Full Papers
    3. Errata
    4. Current Awareness
    1. You have free access to this content

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