Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

January/February 2009

Volume 4, Issue 1

Pages 1–49

  1. Reviews

    1. Top of page
    2. Reviews
    3. Full Papers
    4. Short Communications
    5. Current Awareness
    1. Classification and basic properties of contrast agents for magnetic resonance imaging (pages 1–23)

      Carlos F. G. C. Geraldes and Sophie Laurent

      Article first published online: 20 JAN 2009 | DOI: 10.1002/cmmi.265

      Thumbnail image of graphical abstract

      MRI contrast agents are classified using a combination of several criteria, including chemical composition, magnetic properties and effect on the image. Information on the properties of many compounds studied is presented in a systematic way. These include extracellular, blood pool, hepatobiliary, brain, oral, targeted, smart, CEST and hyperpolarized agents.

  2. Full Papers

    1. Top of page
    2. Reviews
    3. Full Papers
    4. Short Communications
    5. Current Awareness
    1. Internalization of annexin A5-functionalized iron oxide particles by apoptotic Jurkat cells (pages 24–32)

      Geralda A. F. van Tilborg, Tessa Geelen, Hans Duimel, Paul H. H. Bomans, Peter M. Frederik, Honorius M. H. F. Sanders, Niko M. Deckers, Roel Deckers, Chris P. M. Reutelingsperger, Gustav J. Strijkers and Klaas Nicolay

      Article first published online: 9 JAN 2009 | DOI: 10.1002/cmmi.261

      Thumbnail image of graphical abstract

      Annexin A5-functionalized iron oxide particles can be used for the detection of apoptosis with MRI. The present study showed that co-incubation of Jurkat cells with the apoptotic stimulus and the annexin A5 nanoparticles leads to membrane-association and internalization of the contrast agent. In contrast, only membrane-associated annexin A5 nanoparticles were observed when incubation was performed after induction of apoptosis. Only little differences were observed between the ΔR2ΔR2 and ΔR2ΔR1 ratios of cell pellets with membrane-associated or internalized annexin A5 nanoparticles.

  3. Short Communications

    1. Top of page
    2. Reviews
    3. Full Papers
    4. Short Communications
    5. Current Awareness
    1. Effects of radiation on the NMR relaxation effects of aqueous solutions of gadolinium contrast agents (pages 33–36)

      David H. Gultekin, Thomas E. Raidy and John C. Gore

      Article first published online: 5 DEC 2008 | DOI: 10.1002/cmmi.259

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      We investigate the effects of radiation on aqueous solutions of Gd-DTPA, Gd-HP-DO3A and Gd-DTPA + metabolites (N-acetylaspartate, choline, creatine and myo-inositol) using a 6 MV linear accelerator and 1.5 T MRI. The effects of radiation dose and temperature on relaxivities were compared over the ranges of 30 Gy and 4 K, respectively. Radiation caused small increases (1% or less at 20 Gy) in the relaxivities of solutions. The effects of radiation on relaxivities were much smaller than the effects of temperature.

    2. Increased myocardial wall thickening as index of viability assessment: a preliminary report on delayed contrast MRI (pages 37–41)

      Rakesh Sharma and Jose K. Katz

      Article first published online: 20 JAN 2009 | DOI: 10.1002/cmmi.260

      Thumbnail image of graphical abstract

      Delayed contrast-enhanced MRI may detect the inferior wall thickening and apex as an index of viable myocardium better than 201Tl SPECT imaging. Delayed contrast-enhanced MRI enhances both diagnostic accuracy and specificity of measurement of myocardial wall thickness. Myocardial viability may predict functional recovery after revascularization in ischemic cardiomyopathy. Each technique has own merits and disadvantages. Extramurality and myocardial thickness measurement provides a window to evaluate myocardial viability and its recovery with real-time mode.

  4. Current Awareness

    1. Top of page
    2. Reviews
    3. Full Papers
    4. Short Communications
    5. Current Awareness
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