Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

May/June 2009

Volume 4, Issue 3

Pages 109–155

  1. Full Papers

    1. Top of page
    2. Full Papers
    3. Short communications
    4. Current Awareness
    1. Study of the MR relaxation of microglia cells labeled with Gd-DTPA-bearing nanoparticles (pages 109–117)

      Emeline Julie Ribot, Sylvain Miraux, Marie-Hélène Delville, Véronique Bouchaud, Sabrina Lacomme, Etienne Gontier, Anne-Karine Bouzier-Sore, Jean-Michel Franconi, Eric Thiaudiere and Pierre Voisin

      Version of Record online: 9 MAR 2009 | DOI: 10.1002/cmmi.268

      Thumbnail image of graphical abstract

      Fluorescence microscopy images showed that, although most of the gadolinium grafted silica nanoparticles were internalized, some remained adsorbed on the membrane surface. The R1 relaxation rate measurements allowed quantification of the internalized and adsorbed nanoparticles during the time. In spite of a release of the bound contrast agents, the cell population was still detectable by MRI after 4 days of cell growth. These results highlight compartmentalization of nanoparticles in microglia and evolution of the MR signal of the labeled cells.

    2. Functional characterization of mesenchymal stem cells labeled with a novel PVP-coated superparamagnetic iron oxide (pages 118–126)

      Alavala Matta Reddy, Byung Kook Kwak, Hyung Jin Shim, Chiyoung Ahn, Sun Hang Cho, Byung Jin Kim, Sang Young Jeong, Sung-Joo Hwang and Soon Hong Yuk

      Version of Record online: 23 MAR 2009 | DOI: 10.1002/cmmi.271

      Thumbnail image of graphical abstract

      Human bone marrow-derived mesenchymal stem cells (hBMMSC) were labeled with a novel polyvinyl pyrrolidone (PVP)-coated SPIO. There were no signs of cytotoxicity, even at concentrations of up to 1600 μg Fe/ml of the nanoparticles, and the labeled cells were successfully visualized by in vitro cellular MRI. The novel PVP-SPIO nanoparticles appear to be efficient MR contrasting agents and may enable non-invasive in vivo tracking of stem cells in experimental and clinical settings during cell therapy.

    3. DCE-MRI in experimental chronic pancreatitis (pages 127–134)

      Jian Shu, Xiao Ming Zhang, Jian Nong Zhao, Lin Yang, Nan Ling Zeng and Zhao Hua Zhai

      Version of Record online: 27 MAR 2009 | DOI: 10.1002/cmmi.273

      Thumbnail image of graphical abstract

      The purpose of this study was to assess pancreatic perfusion in experimental chronic pancreatitis (CP) by DCE MRI. DCE MRI has a potential to detect and to grade moderate to advanced experimental CP. The SS and TTP of the SI-T curves on pancreatic DCE MRI are related to the severity of CP, and can reflect the decreasing pancreatic blood flow followed by the severity.

    4. In vivo visualization of transplanted pancreatic islets by MRI: comparison between in vivo, histological and electron microscopy findings (pages 135–142)

      Pasquina Marzola, Biancamaria Longoni, Erzsebet Szilagyi, Flavia Merigo, Elena Nicolato, Silvia Fiorini, Giacomo T. Paoli, Donatella Benati, Franco Mosca and Andrea Sbarbati

      Version of Record online: 1 JUN 2009 | DOI: 10.1002/cmmi.274

      Thumbnail image of graphical abstract

      Pancreatic islets, labeled with Endorem® or Resovist®, transplanted in allogeneic rats, originate hypointense spots in liver MR images. Three days after transplantation one spot for every three to four transplanted islets was observed. The time course of MR images showed a decrease in the number of spots which, at 42 days, amounted to 65 and 22% of the 3-day value, for Resovist® and Endorem®, respectively, while no immunopositive endocrine was detected in histological slices. Such findings could indicate the presence of false positive signal in long-term MR images.

  2. Short communications

    1. Top of page
    2. Full Papers
    3. Short communications
    4. Current Awareness
    1. Modulating the relaxivity of hyperpolarized substrates with gadolinium contrast agents (pages 143–147)

      Cristina Gabellieri, Martin O. Leach and Thomas R. Eykyn

      Version of Record online: 27 MAR 2009 | DOI: 10.1002/cmmi.272

      Thumbnail image of graphical abstract

      Gadolinium contrast agents have a pronounced effect on the outer sphere relaxivities of heteronuclei such as 13C or 15N. Clinical contrast agents can be used in conjunction with hyperpolarization techniques to modulate the relaxation times of these nuclei and by way of illustration we show that injection of a bolus of contrast agent into an aqueous solution containing hyperpolarized 15N labeled tetramethylammonium or 13C labeled pyruvate leads to a predictable shortening of the lifetime of the hyperpolarized signal.

  3. Current Awareness

    1. Top of page
    2. Full Papers
    3. Short communications
    4. Current Awareness

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