Methods for an improved detection of the MRI-CEST effect (pages 237–247)
Enzo Terreno, Joseph Stancanello, Dario Longo, Daniela Delli Castelli, Luciano Milone, Honorius M. H. F. Sanders, Maarten B. Kok, Fulvio Uggeri and Silvio Aime
Version of Record online: 16 OCT 2009 | DOI: 10.1002/cmmi.290
Methods for calculating the magnitude of MR-CEST contrast have been developed and tested in silico, in vitro and in vivo. The net improvement obtained by applying the proposed methods with respect to the currently used, standard, CEST assessment relies on the exploitation of the Z-spectrum data. The new approaches lower the detection threshold of CEST agents, thus improving the overall potential of these agents.