Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

May/June 2010

Volume 5, Issue 3

Pages 121–178

  1. Full Papers

    1. Top of page
    2. Full Papers
    3. Current Awareness
    1. Improved synthesis of DOTA tetraamide ligands for lanthanide(III) ions: A tool for increasing the repertoire of potential PARACEST contrast agents for MRI and/or fluorescent sensors (pages 121–125)

      Luis M. De León-Rodríguez, Subha Viswanathan and A. Dean Sherry

      Version of Record online: 31 MAR 2010 | DOI: 10.1002/cmmi.371

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      A simple procedure for the synthesis of DOTA tetra-amide ligands has been developed. This methodology was successfully applied for the solution phase synthesis of DOTA peptide derivatives using DOTA and tert-butyl ester amino acid derivatives as building blocks.

    2. Development of magnetic chromatography to sort polydisperse nanoparticles in ferrofluids (pages 126–132)

      Delphine Forge, Yves Gossuin, Alain Roch, Sophie Laurent, Luce Vander Elst and Robert N. Muller

      Version of Record online: 7 MAY 2010 | DOI: 10.1002/cmmi.374

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      A new magnetic separation called magnetic chromatography was developed for ferrofluids. It clearly allows a refinement of the particle size distribution. This technique significantly improves the properties of the magnetic fluids according to the targeted application.

    3. Patlak plot analysis CT-GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs (pages 133–139)

      K. Alexander, S. Authier, J. R. E. del Castillo, V. Arora, S. Qi, M. Guillot, G. Beauchamp and E. Troncy

      Version of Record online: 29 MAR 2010 | DOI: 10.1002/cmmi.372

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      CT-derived renal plasma clearance was significantly lower in dogs having undergone autologous renal transplant and a relationship was seen between serum creatinine and total renal plasma clearance. CT-GFR appears useful in evaluating renal transplant models.

    4. Serine- and mannose-modified liposomal contrast agent for computed tomography: evaluation of the enhancement in rabbit liver VX-2 tumor model (pages 140–146)

      Masahiro Okada, Takeshi Isoda, Seishi Kumano, Yuki Kagawa, Tetsuro Araki, Hiromitsu Onishi, Masatoshi Hori, Tonsok Kim, Yasuyuki Motokui, Takeshi Wada and Takamichi Murakami

      Version of Record online: 25 MAR 2010 | DOI: 10.1002/cmmi.377

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      Iodinated liposomal contrast agent (ILCA) with serine and mannose modification has not been previously examined for liver enhancement. From 10 to 40 min after injection, the mean enhancement value of the liver parenchyma ROI approached 45 HU for serine-modified ILCA and 34 HU for mannose-modified ILCA. Newly developed ILCAs, such as serine-modified or mannose-modified ILCA, provide sufficient liver parenchymal enhancement at both the dynamic and delayed liver phases.

    5. Liposome contrast agent for CT-based detection and localization of neoplastic and inflammatory lesions in rabbits: validation with FDG-PET and histology (pages 147–154)

      Jinzi Zheng, Christine Allen, Stefano Serra, Douglass Vines, Martin Charron and David A. Jaffray

      Version of Record online: 25 MAY 2010 | DOI: 10.1002/cmmi.378

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      The goal of this investigation was to demonstrate the ability of a novel liposome-based CT contrast agent to localize in tumor and inflammation sites. Specifically, the performance of the liposome agent in CT was compared to that of FDG-PET. A comprehensive histopathology investigation was also conducted on the tumor and inflammatory lesions to confirm their pathogenesis. The successful translation of this liposome agent into the clinics could have a significant impact on CT-based disease screening, diagnosis, and image-guided biopsy procedures.

    6. Assessment of tumor angiogenesis: dynamic contrast-enhanced MRI with paramagnetic nanoparticles compared with Gd-DTPA in a rabbit Vx-2 tumor model (pages 155–161)

      Andrea Kassner, Rebecca E. Thornhill, Fang Liu, Patrick M. Winter, Shelton D. Caruthers, Samuel A. Wickline and Gregory M. Lanza

      Version of Record online: 28 APR 2010 | DOI: 10.1002/cmmi.380

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      The suitability of paramagnetic nanoparticles for the characterization of tumor angiogenesis is compared with clinical MRI contrast agent (GdDTPA) in terms of dynamic contrast-enhanced MRI estimates of microvascular permeability in a rabbit Vx-2 tumor model. Unlike Gd-DTPA, the permeability MRI maps generated using paramagnetic nanoparticles were able to delineate “hotspots” of high permeability within the tumor rim. This suggests that paramagnetic nanoparticles may be suitable for detecting and monitoring tumor angiogenesis.

    7. High-throughput screening of chemical exchange saturation transfer MR contrast agents (pages 162–170)

      Guanshu Liu, Assaf A. Gilad, Jeff W. M. Bulte, Peter C. M. van Zijl and Michael T. McMahon

      Version of Record online: 19 MAY 2010 | DOI: 10.1002/cmmi.383

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      A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, which allows simultaneous testing of multiple CEST agents with minimal attention to shimming and sample configuration. We demonstrate that this can be used to rapidly screen a library of 16 polypeptides for their CEST properties. This method is inexpensive, quick, and tolerant to inhomogeneities in the main magnetic field, and therefore applicable for the development of DIACEST, paramagnetic and liposome agents.

  2. Current Awareness

    1. Top of page
    2. Full Papers
    3. Current Awareness