Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

Special Issue: Special Focus: Hybrid Systems

July/August 2010

Volume 5, Issue 4

Pages 179–244

  1. Editorials

    1. Top of page
    2. Editorials
    3. Review Papers
    4. Reviews
    5. Full Papers
    6. Short Communications
    7. Current Awareness
    1. Special focus: hybrid systems (page 179)

      Peter A. Rinck

      Version of Record online: 27 AUG 2010 | DOI: 10.1002/cmmi.400

  2. Review Papers

    1. Top of page
    2. Editorials
    3. Review Papers
    4. Reviews
    5. Full Papers
    6. Short Communications
    7. Current Awareness
    1. Multimodality imaging techniques (pages 180–189)

      Luis Martí-Bonmatí, Ramón Sopena, Paula Bartumeus and Pablo Sopena

      Version of Record online: 28 MAY 2010 | DOI: 10.1002/cmmi.393

      Thumbnail image of graphical abstract

      Multimodality imaging techniques will play a leading role in relevant clinical applications. Development of new tracers, smart probes and efficient electronics systems capable of detecting two modalities signals at the same time is key and will condition the multimodality image future. Not only MR but also US, optic technology and even MR-diffusion weighted, pharmacokinetic imaging, spectroscopy or functional BOLD imaging will be merge with PET tracers to further increased molecular imaging as a relevant medical discipline.

  3. Reviews

    1. Top of page
    2. Editorials
    3. Review Papers
    4. Reviews
    5. Full Papers
    6. Short Communications
    7. Current Awareness
    1. PET/CT in cancer research: from preclinical to clinical applications (pages 190–200)

      S. Del Vecchio, A. Zannetti, R. Fonti, F. Iommelli, L. M. Pizzuti, A. Lettieri and M. Salvatore

      Version of Record online: 23 MAR 2010 | DOI: 10.1002/cmmi.368

      Thumbnail image of graphical abstract

      In vivo evaluation of complex biological processes such as proliferation, apoptosis, angiogenesis, metastatic dissemination, receptor expression and glucose consumption in human cancers is feasible using PET/CT and radiolabeled molecular probes. Herein we review major preclinical and clinical applications of PET/CT in cancer research.

  4. Full Papers

    1. Top of page
    2. Editorials
    3. Review Papers
    4. Reviews
    5. Full Papers
    6. Short Communications
    7. Current Awareness
    1. Evaluation of the radiation dose in micro-CT with optimization of the scan protocol (pages 201–207)

      Inneke Willekens, Nico Buls, Tony Lahoutte, Luc Baeyens, Christian Vanhove, Vicky Caveliers, Rudi Deklerck, Axel Bossuyt and Johan de Mey

      Version of Record online: 27 JUL 2010 | DOI: 10.1002/cmmi.394

      Thumbnail image of graphical abstract

      Micro-CT provides non-invasive anatomic evaluation of small animals; however, serial micro-CT measurements are hampered by the severity of ionizing radiation doses cumulating over the total period of follow-up. The dose levels are relatively high and may be sufficient to influence experimental outcomes such as animal survival or tumor growth. We believe that the presented adaptation of the scan protocol allows for accurate imaging without the risk of interfering with the experimental outcome of the study.

    2. SPECT/CT hybrid imaging; with which CT? (pages 208–212)

      Tore Bach-Gansmo, Thomas Schwarzlmüller, Vivi Jøraholmen, Jan Salbu, Martin Biermann, Alexandru Naum and Nina Kleven-Madsen

      Version of Record online: 28 APR 2010 | DOI: 10.1002/cmmi.375

      Thumbnail image of graphical abstract

      The aim of this study is to show the practical use of, and to discuss the rationale for, high-end computed tomography (CT) integrated with intrinsic low-resolution single-photon emission tomography (SPECT). All examinations performed on three new SPECT/CT systems with diagnostic CT capabilities were recorded retrospectively. The use of CT was classified as low-dose, using the CT with restraint as to the tube current and radiation dose, or diagnostic, with an optimum use of the CT, using CT protocols as used in ordinary radiological practice.

    3. Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity (pages 213–222)

      Lorenzo Tei, Galit Mazooz, Yael Shellef, Reut Avni, Katrien Vandoorne, Alessandro Barge, Vyacheslav Kalchenko, Mark W. Dewhirst, Linda Chaabane, Luigi Miragoli, Dario Longo, Michal Neeman and Silvio Aime

      Version of Record online: 28 MAY 2010 | DOI: 10.1002/cmmi.392

      Thumbnail image of graphical abstract

      A novel substrate responsive to transglutaminase optimized by molecular modeling calculations (DCCP16) was coupled both to a Gd–DOTA-like complex and to a fluorophore with the aim at providing molecular imaging of enzymatic activity by MRI and by near-infrared imaging. Results show covalent binding of these contrast agents to human clots, to basement membrane components with a prolonged retention in clots and tumors demonstrating the ability to detect both factor XIII and tissue transglutaminase activities.

    4. Tuftsin derivatives of FITC, Tb–DOTA or Gd–DOTA as potential macrophage-specific imaging biomarkers (pages 223–230)

      Jianghua Feng, Marco M. Meloni, Stuart M. Allan, Stephen Faulkner, Johanna Narvainen, Rishma Vidyasagar and Risto Kauppinen

      Version of Record online: 27 MAY 2010 | DOI: 10.1002/cmmi.381

      Thumbnail image of graphical abstract

      Tb–DOTA–tuftsin/pentapeptide and Gd–DOTA–tuftsin conjugates were evaluated as promising optical reagents and as a cell-specific MRI contrast agent to probe the immune response with involvement of macrophage, respectively. Tuftsin receptor-specific biological-function domain may have a modified in vivo biodistribution profile, bioavailability and pharmacokinetics.

  5. Short Communications

    1. Top of page
    2. Editorials
    3. Review Papers
    4. Reviews
    5. Full Papers
    6. Short Communications
    7. Current Awareness
    1. A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging (pages 231–236)

      Matti M. van Schooneveld, David P. Cormode, Rolf Koole, J. Timon van Wijngaarden, Claudia Calcagno, Torjus Skajaa, Jan Hilhorst, Dannis C. 't Hart, Zahi A. Fayad, Willem J. M. Mulder and Andries Meijerink

      Version of Record online: 7 MAY 2010 | DOI: 10.1002/cmmi.376

      Thumbnail image of graphical abstract

      A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging.

  6. Current Awareness

    1. Top of page
    2. Editorials
    3. Review Papers
    4. Reviews
    5. Full Papers
    6. Short Communications
    7. Current Awareness

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