Contrast Media & Molecular Imaging

Cover image for Vol. 5 Issue 5

September/October 2010

Volume 5, Issue 5

Pages 247–304

  1. Full Papers

    1. Top of page
    2. Full Papers
    3. Short Communications
    4. Current Awareness
    1. Variations in labeling protocol influence incorporation, distribution and retention of iron oxide nanoparticles into human umbilical vein endothelial cells (pages 247–257)

      Sandra T. van Tiel, Piotr A. Wielopolski, Gavin C. Houston, Gabriel P. Krestin and Monique R. Bernsen

      Article first published online: 19 MAY 2010 | DOI: 10.1002/cmmi.379

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      Various studies have shown that various cell types can be labeled with iron oxide particles and visualized by magnetic resonance imaging (MRI). However, reported protocols for cell labeling show a large variation in terms of labeling dose and incubation time. It is therefore not clear how different labeling protocols may influence labeling efficiency.

    2. Iron oxide particles covered with hexapeptides targeted at phosphatidylserine as MR biomarkers of tumor cell death (pages 258–267)

      K. A. Radermacher, S. Boutry, S. Laurent, L. Vander Elst, I. Mahieu, C. Bouzin, J. Magat, V. Gregoire, O. Feron, R. N. Muller, B. F. Jordan and B. Gallez

      Article first published online: 28 APR 2010 | DOI: 10.1002/cmmi.382

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      The aim was to develop a molecular marker for non invasive monitoring of tumor cell death as a response to treatment. The phosphatidylserinetargeted peptide E3 was coupled to ultrasmall particles of iron oxide (USPIO). The After intravenous injection of the grafted or ungrafted USPIO, their concentration was evaluated in irradiated tumors by EPR and MRI in vivo. The major finding of the present investigation is that USPIO-PEG750-E3 allows the sensitive detection of tumor cell death after cytotoxic treatment.

    3. Imaging monocytes with iron oxide nanoparticles targeted towards the monocyte integrin MAC-1 (CD11b/CD18) does not result in improved atherosclerotic plaque detection by in vivo MRI (pages 268–275)

      C. von zur Muhlen, A. Fink-Petri, J. Salaklang, D. Paul, I. Neudorfer, V. Berti, A. Merkle, K. Peter, C. Bode and D. von Elverfeldt

      Article first published online: 7 MAY 2010 | DOI: 10.1002/cmmi.384

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      We constructed a MRI contrast agent recognizing monocytes such as found in atherosclerotic plaques by targeting the integrin MAC-1. In vitrostudies suggested an enhanced uptake of CD11b-targeted iron oxide nanoparticles, whereas in ApoE knockout-mice no improved uptake was detected by in vivo MRI. Although these data do not support the application of CD11b-targeted iron oxide nanoparticles for the detection of stable atherosclerotic plaques, the impressive correlation between MRI and histology encourages further development of contrast agents for vulnerable plaque imaging.

    4. Highly constrained backprojection for improving dynamic 3He MR ventilation imaging in rats (pages 276–285)

      Katarzyna Cieślar, Achraf Al Faraj, Vasile Stupar, Sophie Gaillard and Yannick Crémillieux

      Article first published online: 14 MAY 2010 | DOI: 10.1002/cmmi.385

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      The study demonstrates the feasibility of using the 2D HYPR technique for ventilation protocols involving insufflation and spontaneous breathing of 3He in small animals. Additionally, the HYPR algorithm was applied to accelerate T2* mapping of the lungs. Apparent transverse relaxation time maps were obtained at the inspiration and expiration phases of the breathing cycle. The quality and accuracy of image readouts were shown to improve with the application of the I-HYPR variant of the algorithm.

    5. Cytotoxicity of iron oxide nanoparticles made from the thermal decomposition of organometallics and aqueous phase transfer with Pluronic F127 (pages 286–293)

      Marcela Gonzales, Lee M. Mitsumori, John V. Kushleika, Michael E. Rosenfeld and Kannan M. Krishnan

      Article first published online: 7 JUL 2010 | DOI: 10.1002/cmmi.391

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      Magnetic nanoparticles are promising molecular imaging agents due to their relative high relaxivity and the potential to modify surface functionality to tailor biodistribution. This report demonstrates that a monodispersion of organometallic nanoparticles of uniform size and shape can be manufactured. Since the toxicity of the new agent depended upon the synthesis method used, cytotoxicity testing of new molecular imaging agents could be important to clarify which agents can be used for further biological studies.

  2. Short Communications

    1. Top of page
    2. Full Papers
    3. Short Communications
    4. Current Awareness
    1. Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: metal-induced oligomerization of dota–bisphosphonate conjugates (pages 294–296)

      Vojtěch Kubíček, Tomáš Vitha, Jan Kotek, Petr Hermann, Luce Vander Elst, Robert N. Muller, Ivan Lukeš and Joop A. Peters

      Article first published online: 19 MAY 2010 | DOI: 10.1002/cmmi.386

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      A new type of the ion-responsive MRI probe based on bisphosphonate-bearing DOTA-like complexes is evaluated. The formation of the coordination oligomers with biogenic metal ions leads to an unprecedented increase in r1 up to 200–500% along the whole 1H NMRD profile.

  3. Current Awareness

    1. Top of page
    2. Full Papers
    3. Short Communications
    4. Current Awareness
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