Iron oxide particles covered with hexapeptides targeted at phosphatidylserine as MR biomarkers of tumor cell death (pages 258–267)
K. A. Radermacher, S. Boutry, S. Laurent, L. Vander Elst, I. Mahieu, C. Bouzin, J. Magat, V. Gregoire, O. Feron, R. N. Muller, B. F. Jordan and B. Gallez
Article first published online: 28 APR 2010 | DOI: 10.1002/cmmi.382
The aim was to develop a molecular marker for non invasive monitoring of tumor cell death as a response to treatment. The phosphatidylserinetargeted peptide E3 was coupled to ultrasmall particles of iron oxide (USPIO). The After intravenous injection of the grafted or ungrafted USPIO, their concentration was evaluated in irradiated tumors by EPR and MRI in vivo. The major finding of the present investigation is that USPIO-PEG750-E3 allows the sensitive detection of tumor cell death after cytotoxic treatment.