Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

January/February 2011

Volume 6, Issue 1

Pages i–ii, 1–59

  1. Editorial Board

    1. Top of page
    2. Editorial Board
    3. Full Papers
    4. Short Communications
    1. Issue Information (pages i–ii)

      Article first published online: 24 FEB 2011 | DOI: 10.1002/cmmi.437

  2. Full Papers

    1. Top of page
    2. Editorial Board
    3. Full Papers
    4. Short Communications
    1. Background migration of USPIO/MLs is a major drawback for in situ labeling of endogenous neural progenitor cells (pages 1–6)

      Ruth Vreys, Stefaan J. H. Soenen, Marcel De Cuyper and Annemie Van der Linden

      Article first published online: 20 JUL 2010 | DOI: 10.1002/cmmi.390

      Thumbnail image of graphical abstract

      We investigated the potential of magnetoliposomes (MLs) to label endogenous neuronal progenitor cells (NPCs) after direct injection of MLs (neutral, anionic and cationic) into the adult mouse brain at the level of the RMS. Whereas MRI revealed contrast relocation towards the olfactory bulb after injection of MLs, our data strongly imply that this relocation was independent of the migration of endogenous NPCs but represents background migration of MLs along a white matter tract.

    2. Mesenchymal stem cell labeling and in vitro MR characterization at 1.5 T of new SPIO contrast agent: Molday ION Rhodamine-B™ (pages 7–18)

      Benjamin Addicott, Melissa Willman, Jose Rodriguez, Kyle Padgett, Dongmei Han, Dora Berman, Joshua M. Hare and Norma Sue Kenyon

      Article first published online: 5 AUG 2010 | DOI: 10.1002/cmmi.396

      Thumbnail image of graphical abstract

      This study evaluates the feasibility of using a new SPIO contrast agent, Molday ION Rh-B for in vivo cell tracking with MRI. Mesenchymal stem cells (MSC) from nonhuman primates were labeled and assessed for intracellular Fe content distribution. MRI properties for labeled MSC were characterized at 1.5 T and optimal imaging sequences were determined based upon maximizing contrast-to-noise ratio.

    3. Quantitative 1H MRI, 19F MRI, and 19F MRS of cell-internalized perfluorocarbon paramagnetic nanoparticles (pages 19–27)

      Maarten B. Kok, Anke de Vries, Desiree Abdurrachim, Jeanine J. Prompers, Holger Grüll, Klaas Nicolay and Gustav J. Strijkers

      Article first published online: 21 JUL 2010 | DOI: 10.1002/cmmi.398

      Thumbnail image of graphical abstract

      In vivo molecular imaging with targeted MRI contrast agents will require sensitive methods to quantify local concentrations of contrast agent. A targeted paramagnetic perfluorocarbon emulsion permits high-resolution 1H MRI combined with quantitative 19F MRI or MRS. In this study we performed in vitro investigations to test whether 1H and 19F MR signals are linear with concentration and can be quantified from the signal in case the emulsion nanoparticles are shuttled into an intracellular compartment by targeting the ανβ3-integrin cell-internalizing receptor.

    4. Dynamic contrast-enhanced computed tomography for the quantification of tumor response to vasoactive agents in a rat tumor model: preliminary results (pages 28–34)

      Rachel E. Pollard and Richard F. Larson

      Article first published online: 5 AUG 2010 | DOI: 10.1002/cmmi.399

      Thumbnail image of graphical abstract

      Dynamic contrast-enhanced CT was used to measure changes in blood flow induced by vasoactive drugs in a rat tumor model. Alterations in tumor blood flow were identified and the percentage change agreed with a validated estimate of tumor perfusion and oxygenation. This research method may be used to less invasively approximate tumor oxygenation.

    5. Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque (pages 35–45)

      Glenda S. van Bochove, Leonie E.M. Paulis, Dolf Segers, Willem J.M. Mulder, Rob Krams, Klaas Nicolay and Gustav J. Strijkers

      Article first published online: 29 SEP 2010 | DOI: 10.1002/cmmi.402

      Thumbnail image of graphical abstract

      In this study the intrinsic ability of three differently sized gadolinium-based contrast agents to permeate different mouse plaque phenotypes was evaluated with MRI. Gd-HP-DO3A and paramagnetic micelles were found to enhance T1-weighted MR images of the plaques, whereas paramagnetic liposomes did not cause significant plaque enhancement. This knowledge can be used to improve the design of targeted contrast agents directed towards specific markers of vulnerable and stable plaque.

    6. Modification of MR molecular imaging probes with cysteine-terminated peptides and their potential for in vivo tumour detection (pages 46–54)

      Fenghua Xu, Du Lei, Xiaoxia Du, Chunfu Zhang, Xuan Xie and Duanzhi Yin

      Article first published online: 22 SEP 2010 | DOI: 10.1002/cmmi.403

      Thumbnail image of graphical abstract

      MR molecular imaging probe fabricated by cysteine-terminated small peptide replacement with oleic acid is able to target tumor cells in vitro as well tumor in vivo.

  3. Short Communications

    1. Top of page
    2. Editorial Board
    3. Full Papers
    4. Short Communications
    1. Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle (pages 55–59)

      Nobuyuki Kosaka, Makoto Mitsunaga, Sukanta Bhattacharyya, Steven C. Miller, Peter L. Choyke and Hisataka Kobayashi

      Article first published online: 28 MAY 2010 | DOI: 10.1002/cmmi.395

      Thumbnail image of graphical abstract

      In vivo lymphatic image produced with a self-illuminating bioluminescence resonance energy transfer quantum dot nano-particle demonstrates absence of background signal and superior quantification.

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