Contrast Media & Molecular Imaging

Cover image for Vol. 6 Issue 3

May/June 2011

Volume 6, Issue 3

Pages i–iii, 119–167

  1. Editorial Board

    1. Top of page
    2. Editorial Board
    3. Full Papers
    4. Short Communications
    1. Issue Information (pages i–iii)

      Article first published online: 23 JUN 2011 | DOI: 10.1002/cmmi.462

  2. Full Papers

    1. Top of page
    2. Editorial Board
    3. Full Papers
    4. Short Communications
    1. Can we accurately quantify nanoparticle associated proteins when constructing high-affinity MRI molecular imaging probes? (pages 119–125)

      Gabriella Rimkus, Sibylle Bremer-Streck, Cordula Grüttner, Werner Alois Kaiser and Ingrid Hilger

      Article first published online: 23 JUN 2011 | DOI: 10.1002/cmmi.405

      Thumbnail image of graphical abstract

      Direct and reliable quantification of proteins in presence of magnetic nanoparticles containing iron oxide (e.g. targeted high-affinity probes for MRI) via Bradford and BCA protein assays are investigated and established.

    2. Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats (pages 126–131)

      Lee Mullin, Ryan Gessner, James Kwan, Mehmet Kaya, Mark A. Borden and Paul A. Dayton

      Article first published online: 19 JAN 2011 | DOI: 10.1002/cmmi.414

      Thumbnail image of graphical abstract

      This study evaluated differences in circulation times for lipid shelled perfluorocarbon-filled ultrasound contrast agents circulating within rodents as a function of inhaled anesthesia carrier gas. Significantly longer in-vivo contrast agent circulation times were observed in animals breathing medical air compared to breathing pure oxygen. The results were supported by a mathematical diffusion model for 1µm bubbles in a multi-gas environment.

    3. Properties and suspension stability of dendronized iron oxide nanoparticles for MRI applications (pages 132–138)

      B. Basly, D. Felder-Flesch, P. Perriat, G. Pourroy and S. Bégin-Colin

      Article first published online: 30 NOV 2010 | DOI: 10.1002/cmmi.416

      Thumbnail image of graphical abstract

      Depending on the synthetic methods and grafting ways, iron oxide nanoparticles functionalized by dendritic molecules display characteristic magnetic properties and agglomeration states, leading to different relaxivity values, among the best reported for grafted co-precipitated nanoparticles.

    4. A hyperpolarized choline molecular probe for monitoring acetylcholine synthesis (pages 139–147)

      Hyla Allouche-Arnon, Ayelet Gamliel, Claudia. M. Barzilay, Ruppen Nalbandian, J. Moshe Gomori, Magnus Karlsson, Mathilde H. Lerche and Rachel Katz-Brull

      Article first published online: 22 NOV 2010 | DOI: 10.1002/cmmi.418

      Thumbnail image of graphical abstract

      A new hyperpolarized molecular probe, [1,1,2,2-D4,2-13C]choline chloride, enables monitoring of the enzymatic conversion of choline to acetylcholine. The 13C position showed a long T1 of 35 s and a sufficient chemical shift resolution of 2.9 ppm. Following 1.5 h of dynamic nuclear polarization a 24 % polarization has been achieved in liquid state. The T1 of the newly formed hyperpolarized [1,1,2,2-D4,2-13C]acetylcholine was 34 s. We find this new molecular probe to be promising for hyperpolarized metabolic studies.

  3. Short Communications

    1. Top of page
    2. Editorial Board
    3. Full Papers
    4. Short Communications
    1. Optimizing quantitative in vivo fluorescence imaging with near-infrared quantum dots (pages 148–152)

      Lauren T. Rosenblum, Nobuyuki Kosaka, Makoto Mitsunaga, Peter L. Choyke and Hisataka Kobayashi

      Article first published online: 8 OCT 2010 | DOI: 10.1002/cmmi.409

      Thumbnail image of graphical abstract

      Quantum dots (QDs) are fluorescent nanoparticles with broad excitation and narrow, wavelength-tunable emission spectra. Although a range of wavelengths can be selected for in vitro fluorescence imaging with QDs, in vivo imaging is constrained by factors including scattering and absorption by tissue. Here, we demonstrate that longer-wavelength excitation and emission yield less error in relative fluorescence intensity, using three near-infrared QDs (QD655, QD705, and QD800) and a range of excitation wavelengths from the blue to the red.

    2. How to assess cytotoxicity of (iron oxide-based) nanoparticles. A technical note using cationic magnetoliposomes (pages 153–164)

      Stefaan J.H. Soenen and Marcel De Cuyper

      Article first published online: 1 DEC 2010 | DOI: 10.1002/cmmi.415

      Thumbnail image of graphical abstract

      Labelling of stem or therapeutic cells with iron oxide nanoparticles is a common practice in biomedical research, which requires a thorough and in-depth analysis of cell-nanoparticle interactions to exclude toxicity and undesired side-effects of the labelling procedure. In this technical paper, an overview of several (commonly used and recently established) assays to analyze cell viability, morphology, functionality and physiology are presented. The different methods are compared with one another and useful notes are given which could aid any researcher interested in evaluating the safety of cell labelling by nanoparticles.

    3. NMR Determination of Free Gallium(III) Ions in Aqueous Solutions of Ga complexes, “Cold” Analogs of PET/SPECT Tracers (pages 165–167)

      Q. Zhou, C. Henoumont, L. Vander Elst, S. Laurent and R.N. Muller

      Article first published online: 23 JUN 2011 | DOI: 10.1002/cmmi.441

      Thumbnail image of graphical abstract

      A nephrotoxic compound tetrahedral [Ga(OH)4], as one kind of soluble free gallium ions, can conceal themselves among Ga-complex aqueous solution and are relatively invisible. Here we show that 71Ga NMR is a useful tool to rapidly detect the presence of [Ga(OH)4] in aqueous solutions of Ga-complexes and to follow the purification steps of the Ga-complex solutions.

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