Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

November/December 2011

Volume 6, Issue 6

Pages 421–522

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Full Papers
    1. Issue Information (pages i–iii)

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.495

  2. Full Papers

    1. Top of page
    2. Issue Information
    3. Full Papers
    1. A novel PET tracer for the imaging of αvβ3 and αvβ5 integrins in experimental breast cancer bone metastases (pages 413–420)

      Ute Mühlhausen, Dorde Komljenovic, Maren Bretschi, Karin Leotta, Michael Eisenhut, Wolfhard Semmler and Tobias Bäuerle

      Article first published online: 9 DEC 2011 | DOI: 10.1002/cmmi.435

      Thumbnail image of graphical abstract

      68Ga-DOTA-E-[c(RGDfK)]2 showed favorable characteristics including an easily adoptable radiosynthesis, high tumor-blood-ratios, target specificity and clear visualization of breast cancer bone metastasis. Therefore our results suggest that this compound is a promising PET tracer for the imaging of αvβ3 and αvβ5 in these osseous metastases.

    2. MRI of cells and mice at 1 and 7 Tesla with Gd-targeting agents: when the low field is better! (pages 421–425)

      Simonetta Geninatti-Crich, Ibolya Szabo, Diego Alberti, Dario Longo and Silvio Aime

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.436

      Thumbnail image of graphical abstract

      A comparison between the efficiency of slowly moving macromolecular MRI imaging probes at 1 and 7 Tesla was carried out using Gd-loaded/LDL (Low Density Lipoproteins) adducts consisting of 250 Gd amphiphilic complexes incorporated in the lipophilic LDL particles. The sensitivity enhancement obtained at 1 Tesla of B16 melanoma cells labeled with Gd–AAZTAC17/LDL adduct is several times higher than that attained at higher fields.

    3. Dynamic manganese-enhanced magnetic resonance imaging can detect chronic cryoinjury-induced infarction in pig hearts in vivo (pages 426–436)

      Yanmin Yang, Patricia Dreessen de Gervai, Jiankang Sun, Marco L. Gruwel and Valery Kupriyanov

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.438

      Thumbnail image of graphical abstract

      Intravenous infusion of 70 μmol/kg MnCl2 (intermittent or continuous) highlighted cryoinjury-induced chronic infarct areas as hypointense zones in T1-weighted MR images, which closely corresponded to hyperintense regions in the late GdDTPA-enhanced images and post-mortem TTC-negative zones. Image contrast was maximized upon Mn2+ clearance from the blood. Hemodynamic effects were minimal during continouos infusion, which makes MnCl2 a safe MR contrast agent for animal applications.

    4. Imaging efficiency of an X-ray contrast agent-incorporated polymeric microparticle (pages 437–448)

      Sungsook Ahn, Sung Yong Jung, Jin Pyung Lee and Sang Joon Lee

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.440

      Thumbnail image of graphical abstract

      An X-ray contrast flow tracer was developed for particle-tracing X-ray imaging technology. The physical properties, especially the hydrodynamic size (DH), of the microparticles suspended in liquid media dominantly influence the imaging efficiency.

    5. The pH sensitivity of –NH exchange in LnDOTA–tetraamide complexes varies with amide substituent (pages 459–464)

      Ana Christina L. Opina, Yunkou Wu, Piyu Zhao, Garry Kiefer and A. Dean Sherry

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.445

    6. The presence of iodinated contrast agents amplifies DNA radiation damage in computed tomography (pages 507–513)

      Caroline Pathe, Katharina Eble, Daniel Schmitz-Beuting, Boris Keil, Bjoern Kaestner, Maximilian Voelker, Beate Kleb, Klaus J. Klose and Johannes T. Heverhagen

      Article first published online: 5 DEC 2011 | DOI: 10.1002/cmmi.453

      Thumbnail image of graphical abstract

      The presence of iodinated contrast agents without simultaneous irradiation does not lead to DNA damage. During irradiation, iodinated contrast agents increased the number of γH2AX-foci by at least 25% in vitro. In vivo, foci levels were 58% higher when contrast agent was present in comparison to unenhanced CT scans.

    7. Labeling of multiple cell lines using a new iron oxide agent for cell tracking by MRI (pages 514–522)

      C. McFadden, C. L. Mallett and P. J. Foster

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.456

      Thumbnail image of graphical abstract

      MRI of mice after injection of MIRB labeled cells. (A) bSSFP image of the mouse brain. 300 000 cells were injected intracardially into the left ventricle of the heart in a nude mouse for delivery to the brain. Arrows indicate individual voids representing single MIRB labeled cells. (B) bSSFP image of the mouse body one day after injection of 1 million 231BRHer2 cells subcutaneously in the flank region.

    8. A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts (pages 449–458)

      Stefania Lanzardo, Laura Conti, Chiara Brioschi, Maria Paola Bartolomeo, Daniela Arosio, Laura Belvisi, Leonardo Manzoni, Alessandro Maiocchi, Federico Maisano and Guido Forni

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.444

      Thumbnail image of graphical abstract

      In this work the sensitivity of DA364 to detect αVβ3 integrin-overexpressing tumors was evaluated. DA364 derives from the conjugation of Cy5.5 with a RGD probe selected among a collection of cyclic peptidomimetics. DA364 displays high binding affinity for αVβ3 integrin and prolonged visualization of glioblastoma xenografts in mice. Its specificity was confirmed by inhibition of tumor uptake in the presence of nonfluorescent RGD peptides, suggesting that DA364 is a promising optical imaging tool for tumor diagnosis and guided surgery.

    9. A novel foam fluid negative contrast medium for clear visualization of the colon wall in CT imaging (pages 465–473)

      Xiaohui Wei, Jiong Zhu, Hongxia Gong, Jianrong Xu and Yuhong Xu

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.446

      Thumbnail image of graphical abstract

      A novel foam fluid negative contrast medium for colon CT imaging was prepared by dispersing a large number of air bubbles in a polymeric solution. Both the stabilities of the individual bubbles and the foam fluid system were optimized by incorporating BSA and gluconolactone as the stabilization agent. Such an oil free contrast medium had a mean x-ray density of −120HU, which resulted in a “dark lumen” effect and enabled the clear 2D visualization of the colonic wall.

    10. β-Cell subcellular localization of glucose-stimulated Mn uptake by X-ray fluorescence microscopy: implications for pancreatic MRI (pages 474–481)

      Lara Leoni, Anita Dhyani, Patrick La Riviere, Stefan Vogt, Barry Lai and B. B. Roman

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.447

      Thumbnail image of graphical abstract

      Subcellular uptake of manganese in MIN-6 insulinoma β-cells was visualized and quantified via X-ray fluorescence microscopy following exposure to 50 µ m MnCl2. Significant increase in manganese was measured under baseline 2 m m glucose conditions and more significantly at activating 16 m m glucose and at 16 m m glucose + 30 m m KCl media formulations. Intracellular manganese distribution changed with its increasing concentration and shifted from homogeneous throughout the whole cell to mainly cytoplasmic.

    11. The Gd3+ complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(p-isothiocyanatoanilide) conjugated to inulin: a potential stable macromolecular contrast agent for MRI (pages 482–491)

      Luigi Granato, Sophie Laurent, Luce Vander Elst, Kristina Djanashvili, Joop A. Peters and Robert N. Muller

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.448

      Thumbnail image of graphical abstract

      Upon conjugation of Gd3+ complex of DOTA-NCSA with the modified polysaccharide inulin (L-API), the longitudinal relaxivity increases from 4.1 to 21.7 s−1 m m−1 at 20 MHz and 37 °C, thanks to efficient slowing down of the molecular tumbling of the Gd-chelate by the inulin carrier. The resulting conjugate shows an extremely high kinetic stability. No transmetalation with Zn2+ ions was observed.

    12. A methodical 68Ga-labelling study of DO2A-(butyl- l-tyrosine)2 with cation-exchanger post-processed 68Ga: practical aspects of radiolabelling (pages 492–498)

      Patrick J. Riss, Carsten Burchardt and Frank Roesch

      Article first published online: 29 NOV 2011 | DOI: 10.1002/cmmi.451

      Thumbnail image of graphical abstract

      Various parameters for the optimization of radiolabelling reactions are elucidated. A multivalent DO2A derivative is used as a model compound. Rapid isolation, purification and preliminary evaluation are described.

    13. Deuteration of a molecular probe for DNP hyperpolarization – a new approach and validation for choline chloride (pages 499–506)

      Hyla Allouche-Arnon, Mathilde H. Lerche, Magnus Karlsson, Robert E. Lenkinski and Rachel Katz-Brull

      Article first published online: 5 DEC 2011 | DOI: 10.1002/cmmi.452

      Thumbnail image of graphical abstract

      Dynamic nuclear polarization (DNP) for hyperpolarized 13C-MRI/MRS of real-time metabolism in vivo is challenged by the physical requirement of a liquid state T1 of tens of seconds, which is mostly found for 13C-carbons in small molecules that have no direct protons attached. The choline molecular agent [1,1,2,2-D4, 2-13C]choline chloride with a deuterated 13C position demonstrated physical properties comparable to a hyperpolarized compound of already proven value, [1-13C]pyruvate. This concept may substantially expand the library of agents for DNP-MR.

SEARCH

SEARCH BY CITATION