An approach towards molecular imaging of activated platelets allows imaging of symptomatic human carotid plaques in a new model of a tissue flow chamber (pages 204–213)
Dominik von Elverfeldt, Mirko Meißner, Karlheinz Peter, Dominik Paul, Fabian Meixner, Irene Neudorfer, Annette Merkle, Andreas Harloff, Andreas Zirlik, Joachim Schöllhorn, Michael Markl, Jürgen Hennig, Christoph Bode and Constantin von zur Muhlen
Version of Record online: 14 MAR 2012 | DOI: 10.1002/cmmi.482
We established molecular MRI of human endarterectomy specimes, allowing detection of activated platelets on the surface of symptomatic plaques by using a platelet-specific contrast agent in a newly constructed setup of an MRI tissue flow chamber, simulating physiological flow conditions inside the specimen. As a perspective, the flow chamber approach described in this study could help to evaluate binding properties of contrast agents, which seem to qualify for human applications after successful use in animal studies, and might therefore be an interesting tool for contrast agent development towards its clinical application.