Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T2 contrast agent with tunable proton relaxivities (pages 460–468)
Fei Ye, Sophie Laurent, Andrea Fornara, Laura Astolfi, Jian Qin, Alain Roch, Alessandro Martini, Muhammet S. Toprak, Robert N. Muller and Mamoun Muhammed
Article first published online: 17 JUL 2012 | DOI: 10.1002/cmmi.1473
Surface coating effects of superparamagnetic iron oxide on MRI T2 contrast enhancement were evaluated based on monodisperse mesoporous silica-coated magnetite nanoparticles (Fe3O4@mSiO2 NPs). Tunable magnetic relaxivities of Fe3O4@mSiO2 NPs were obtained by varying the thickness of mSiO2 coating. The contrast efficiency of Fe3O4@mSiO2 increases with the coating thickness and is more than 20 times higher than that of the commercial contrast agents.