Contrast Media & Molecular Imaging

Cover image for Vol. 7 Issue 5

September/October 2012

Volume 7, Issue 5

Pages 441–483

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communication
    1. Issue Information (pages i–iii)

      Article first published online: 23 JUL 2012 | DOI: 10.1002/cmmi.1488

  2. Full Papers

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communication
    1. DOTAM-type ligands possessing arginine pendant groups for use in PARACEST MRI (pages 441–449)

      Mojmír Suchý, Alex X. Li, Mark Milne, Robert Bartha and Robert H. E. Hudson

      Article first published online: 17 JUL 2012 | DOI: 10.1002/cmmi.1461

      Thumbnail image of graphical abstract

      Tri- and tetra-substituted cyclens possessing arginine pendant groups have been selectively synthesized. The Dy3+ and Tm3+ complexes of the tetrasubsituted ligand display CEST effects that are associated with the amide protons. The signals for the Tm3+ complex are strongly dependent on pH in the physiological range of 6.0–8.0.

    2. In vivo monitoring of antiangiogenic therapy by magnetic resonance and bioluminescence imaging in an M21 tumor model through activation of an hsp70 promoter–luciferase reporter construct (pages 450–459)

      Walter Hundt, Silke Steinbach, Caitlin E. O'Connell-Rodwell, Dirk Mayer, Mykhaylo Burbelko and Samira Guccione

      Article first published online: 23 JUL 2012 | DOI: 10.1002/cmmi.1472

      Thumbnail image of graphical abstract

      We investigated targeted gene therapy on M21 cell line, transfected with hsp70_luciferase or CMV_luciferase using BLI and MRI. Mice were intravenously treated every 72 h with a nanoparticle-Arg-Gly-Asp-peptide-complex, and a dominant negative mutant protein kinase inhibitor gene. Imaging was performed at specific time intervals. Targeted antiangiogenic therapy can induce activation of the hsp70 promoter through a heat shock/luciferase reporter system. MRI showed a significant reduction of the contrast medium uptake and an increase in the diffusion coefficient of the tumors.

    3. Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T2 contrast agent with tunable proton relaxivities (pages 460–468)

      Fei Ye, Sophie Laurent, Andrea Fornara, Laura Astolfi, Jian Qin, Alain Roch, Alessandro Martini, Muhammet S. Toprak, Robert N. Muller and Mamoun Muhammed

      Article first published online: 17 JUL 2012 | DOI: 10.1002/cmmi.1473

      Thumbnail image of graphical abstract

      Surface coating effects of superparamagnetic iron oxide on MRI T2 contrast enhancement were evaluated based on monodisperse mesoporous silica-coated magnetite nanoparticles (Fe3O4@mSiO2 NPs). Tunable magnetic relaxivities of Fe3O4@mSiO2 NPs were obtained by varying the thickness of mSiO2 coating. The contrast efficiency of Fe3O4@mSiO2 increases with the coating thickness and is more than 20 times higher than that of the commercial contrast agents.

    4. Hyperpolarized 13C-labelled anhydrides as DNP precursors of metabolic MRI agents (pages 469–477)

      Sonia Colombo Serra, Magnus Karlsson, Giovanni Battista Giovenzana, Camilla Cavallotti, Fabio Tedoldi and Silvio Aime

      Article first published online: 17 JUL 2012 | DOI: 10.1002/cmmi.1474

      Thumbnail image of graphical abstract

      Hyperpolarized 13C-labelled short chain fatty acids appear to be interesting candidates for in vivo detection of metabolic abnormalities associated of the onset and progression of human diseases.

      In this work it is shown that symmetric anhydrides are suitable chemical precursors which allow to avoid the use of glass-forming agents to achieve proper formulations of short chain fatty acids for Dynamic Nuclear Polarization (DNP). Furthermore, novel esterified trityl radicals and lipophilic gadolinium complexes are shown to be a valuable mean for enabling easy removal of the polarization-promoting additives at the end of the DNP process.

  3. Short Communication

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communication
    1. A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes (pages 478–483)

      Aneta Keliris, Ilgar Mamedov, Gisela E. Hagberg, Nikos K. Logothetis, Klaus Scheffler and Jörn Engelmann

      Article first published online: 23 JUL 2012 | DOI: 10.1002/cmmi.1470

      Thumbnail image of graphical abstract

      We report on a dual-modal 19F and 1H MRI paramagnetic probe with a self-immolative linker. The enzymatic conversion of this probe by β-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the cleaved Gd3+complex to modulate the 1H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by 19F and 1H MRI using this molecular design is proposed.

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