Contrast Media & Molecular Imaging

Cover image for Vol. 7 Issue 6

November/December 2012

Volume 7, Issue 6

Pages i–iii, 485–546

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communications
    1. Issue Information (pages i–iii)

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1495

  2. Full Papers

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communications
    1. Processing of superparamagnetic iron contrast agent ferucarbotran in transplanted pancreatic islets (pages 485–493)

      Klára Zacharovová, Zuzana Berková, Daniel Jirák, Vít Herynek, Marie Vancová, Eva Dovolilová and František Saudek

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1477

      Thumbnail image of graphical abstract

      Although the SPIO particles used for labeling of isolated pancreatic islets were located aside the endocrine cells after islet transplantation, MRI detection of the contrast agent correlated with islet survival and function in islet transplantation into the liver. However, it did not correlate in the case of transplantation beneath the renal capsule.

    2. Comparison of dynamic contrast-enhanced MRI and quantitative SPECT in a rat glioma model (pages 494–500)

      Jack T. Skinner, Thomas E. Yankeelov, Todd E. Peterson and Mark D. Does

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1479

      Thumbnail image of graphical abstract

      DCE-MRI model estimates may be biased by issues such as contrast agent and tissue water dynamics. A quantitative dual-isotope SPECT technique was developed to obtain an estimate of ve in a rat glioma model for comparison to DCE-MRI. A consistent overestimation in the value of ve from the DCE-MRI analysis was found and may be due, in part, to inflow effects, contrast agent diffusion in poorly perfused tumor regions, and assumptions made by the Tofts models.

    3. Enhanced MRI relaxivity of Gd3+-based contrast agents geometrically confined within porous nanoconstructs (pages 501–508)

      Richa Sethi, Jeyarama S. Ananta, Christof Karmonik, Meng Zhong, Steve H. Fung, Xuewu Liu, King Li, Mauro Ferrari, Lon J. Wilson and Paolo Decuzzi

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1480

      Thumbnail image of graphical abstract

      The geometrical confinement of [Gd(DTPA)(H2O)]2- molecules (Magnevist®) within the mesoporous structure of silicon particles enhances their longitudinal relaxivity up to 6 times, without any chemical modification. Geometrical confinement increases the rotational (R) and diffusion (D) correlation times, affecting both the inner- and outer-sphere relaxation contributions. The silicon particles can be readily decorated with ligand molecules for preferential delivery to the tumor vasculature.

    4. Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients (pages 509–515)

      Monika Dezortova, Vit Herynek, Martin Krssak, Claudia Kronerwetter, Siegfried Trattnig and Milan Hajek

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1482

      Thumbnail image of graphical abstract

      Based on the magnetic field dependency of antiferromagnetic ferritin and maghemite iron oxide nanoparticle relaxivities, we derived a two-component model for the description of iron deposits in the globus pallidus of patients with panthotenate-kinase associated neurodegeneration examined at 1.5, 3 and 7T. According to this model, we estimated the iron content in the patients as 391 µg/ml of ferritin and 1.1 µg/ml of ferrimagnetic iron compared with 178 µg/ml of iron in ferritin found in controls.

    5. cGMP-Compatible preparative scale synthesis of near-infrared fluorophores (pages 516–524)

      Hoon Hyun, Mark W. Bordo, Khaled Nasr, Dina Feith, Jeong Heon Lee, Soon Hee Kim, Yoshitomo Ashitate, Lorissa A. Moffitt, Mireille Rosenberg, Maged Henary, Hak Soo Choi and John V. Frangioni

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1484

      Thumbnail image of graphical abstract

      Clinical grade zwitterionic near-infrared (NIR) fluorophore ZW800-1 was prepared for image-guided surgery. We describe cGMP-compatible synthesis of ultrapure ZW800-1 through facile and efficient procedures at the 10-gram scale. ZW800-1 has > 90% yield at the final step and > 99% purity as measured by fluorescence and evaporative light scatter detection. We describe an analytical framework to quantitate impurities, as well as a detailed analysis of counterion identities. The unique in vivo properties of ZW800-1, including rapid renal excretion and low nonspecific background binding were confirmed in large animals approaching the size of humans, thus enabling rapid clinical translation.

    6. Optical imaging of progenitor cell homing to patient-derived tumors (pages 525–536)

      Isabel G. Newton, Warren C. Plaisted, Steven Messina-Graham, Annelie E. Abrahamsson Schairer, Alice Y. Shih, Evan Y. Snyder, Catriona H. M. Jamieson and Robert F. Mattrey

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1485

      Thumbnail image of graphical abstract

      Neural progenitor cells (NPC) home to cancers derived from cell lines. If they also home to tumors grown from patient cancer cells at a level detectable by imaging, this property could be exploited to target malignancies for diagnostic and therapeutic purposes. Using optical imaging, immunohistochemistry and FACS, we demonstrate that C17.2 NPC accumulate in solid CD45-positive tumors at levels detectable by imaging. NPC also accumulate at proportionately lower levels in tissues with micrometastatic foci, which could have significant clinical applications.

  3. Short Communications

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communications
    1. Classification of acute and delayed contrast media-induced reactions: proposal of a three-step system (pages 537–541)

      Ingrid Böhm, Johannes T. Heverhagen and Klaus J. Klose

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1475

      Thumbnail image of graphical abstract

      General descriptions may lead to problems to understand reactions in patients with a history of “adverse CM-reactions”, and to efficiently manage these patients (personalized medicine). We present an easy system to clearly classify these reactions on a three-steps-systems: step 1 ➔ document the clinical diagnosis including its severity, step 2 ➔ notice the time point of onset (immediate or nonimmediate), step 3 ➔ classify the reaction (hypersensitivity or non-hypersensitivity reaction). On the basis of this system secondary prophylaxis will be possible in an individual manner.

    2. Manganese: a new contrast agent for lung imaging? (pages 542–546)

      Oliviero L. Gobbo, Magdalena Zurek, Frederic Tewes, Carsten Ehrhardt and Yannick Crémillieux

      Version of Record online: 18 SEP 2012 | DOI: 10.1002/cmmi.1483

      Thumbnail image of graphical abstract

      Manganese-enhancement MRI (MEMRI) technique was evaluated for T1-enhancement of lung parenchyma. Rat lungs were selectively instilled with 200 µl solutions of manganese chloride at concentrations ranging between 10 μm and 10 mm. MR acquisitions were performed using T1-weighted ultrashort echo time imaging sequence at different flip angles. Lung signal intensity was significantly increased in animal receiving a manganese solution at 1 and 10 mm concentration compared with a control solution.

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