Contrast Media & Molecular Imaging

Cover image for Contrast Media & Molecular Imaging

May/June 2013

Volume 8, Issue 3

Pages 211–331

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Review
    4. Full Papers
    5. Short Communication
    6. Abstracts
    1. Issue Information (pages i–iii)

      Version of Record online: 21 APR 2013 | DOI: 10.1002/cmmi.1505

  2. Review

    1. Top of page
    2. Issue Information
    3. Review
    4. Full Papers
    5. Short Communication
    6. Abstracts
    1. Developments in near-infrared-guided hepatobiliary, pancreatic and other upper gastrointestinal surgery (pages 211–219)

      Dawid Murawa, Karol Polom, Young Soo Rho and Pawel Murawa

      Version of Record online: 11 JAN 2013 | DOI: 10.1002/cmmi.1519

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      Real time utility of NIR and its fluorophores has gained a vast interest amongst surgeons of various sub-disciplines. The purpose of this review is to assess and explore the most recent developments in NIR guided surgery of hepatobiliary, pancreatic, and other upper gastrointestinal surgeries.

  3. Full Papers

    1. Top of page
    2. Issue Information
    3. Review
    4. Full Papers
    5. Short Communication
    6. Abstracts
    1. Synthesis and evaluation of a polydisulfide with Gd–DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging (pages 220–228)

      Zhen Ye, Xueming Wu, Mingqian Tan, Jack Jesberger, Mark Grisworld and Zheng-Rong Lu

      Version of Record online: 11 JAN 2013 | DOI: 10.1002/cmmi.1520

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      A polydisulfide containing Gd–DOTA monoamide side chains, GODC, was synthesized and evaluated as a biodegradable macromolecular MRI contrast agent with high kinetic stability. The chelates in the agent were highly stable against transmetallation with Zn2+ ions and the polymer chains were readily reduced by endogenous thiols to facilitate the excretion of the agent. The agent produced strong and prolonged contrast enhancement in the vasculature and tumor periphery of mice bearing breast cancer xenograft.

    2. SPECT imaging of fibrin using fibrin-binding peptides (pages 229–237)

      Lucas W. E. Starmans, Sander M. J. van Duijnhoven, Raffaella Rossin, Silvio Aime, Mat J. A. P. Daemen, Klaas Nicolay and Holger Grüll

      Version of Record online: 11 JAN 2013 | DOI: 10.1002/cmmi.1521

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      In this study, we show the potential of a novel 111In-labeled fibrin-binding peptide (FibPep) for noninvasive detection of fibrin deposition using SPECT. FibPep and a negative control peptide (NCFibPep) were synthesized and their fibrin-binding properties were assessed in vitro and in vivo. In vivo SPECT imaging using FibPep allowed clear visualization of thrombi. Ex vivo biodistribution showed significantly increased uptake of FibPep in the thrombus-containing carotid in comparison to the noninjured carotid, whereas nonspecific NCFibPep did not.

    3. Imaging integrin alpha-v-beta-3 expression in tumors with an 18F-labeled dimeric RGD peptide (pages 238–245)

      Ingrid Dijkgraaf, Samantha Y. A. Terry, William J. McBride, David M. Goldenberg, Peter Laverman, Gerben M. Franssen, Wim J. G. Oyen and Otto C. Boerman

      Version of Record online: 11 JAN 2013 | DOI: 10.1002/cmmi.1523

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      In this study the angiogenesis-targeting dimeric peptide NODAGA-E-[c(RGDfK)]2 was labeled with 18F using a quick, direct, aqueous and one-pot method. In biodistribution and microPET imaging studies 18F-NODAGA-E-[c(RGDfK)]2 showed specific uptake in integrin αvβ3-expressing SK-RC-52 subcutaneous xenografts in nude BALB/c mice. 18F-NODAGA-E-[c(RGDfK)]2 showed rapid blood clearance as well as good in vivo stability.

    4. Simultaneous experimental determination of labile proton fraction ratio and exchange rate with irradiation radio frequency power-dependent quantitative CEST MRI analysis (pages 246–251)

      Phillip Zhe Sun, Yu Wang, Gang Xiao and Renhua Wu

      Version of Record online: 4 FEB 2013 | DOI: 10.1002/cmmi.1524

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      Because the CEST effect varies with the labile proton content, exchange rate and experimental conditions, the commonly used CEST imaging only provides CEST-weighted information. It has been shown with numerical simulation that labile proton fraction ratio and exchange rate can be simultaneously determined by evaluating the radio frequency (RF) power dependence of CEST effect. The quantitative CEST analysis was demonstrated using two CEST phantoms of serially varied pH and CEST agent concentration, which remains promising to augment the conventional CEST-weighted analysis.

    5. EPR assessment of protein sites for incorporation of Gd(III) MRI contrast labels (pages 252–264)

      Jens O. Lagerstedt, Jitka Petrlova, Silvia Hilt, Antonin Marek, Youngran Chung, Renuka Sriram, Madhu S. Budamagunta, Jean F. Desreux, David Thonon, Thomas Jue, Alex I. Smirnov and John C. Voss

      Version of Record online: 4 FEB 2013 | DOI: 10.1002/cmmi.1518

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      The study demonstrates the excellent utility of EPR technique for screening protein candidates as vehicles for carrying MRI contrast agents. A scaled EPR parameter is shown to correlate with the degree of water proton relaxivity for biomolecular MRI contrast agents. Protein contrast agents can thus be screened by X-band EPR spectroscopy employing both the nitroxide and Gd(III)-DOTA probes at sample volumes in the microliter range.

    6. Spectroscopic, radiochemical, and theoretical studies of the Ga3+-N-2-hydroxyethyl piperazine-N′-2-ethanesulfonic acid (HEPES buffer) system: evidence for the formation of Ga3+- HEPES complexes in 68 Ga labeling reactions (pages 265–273)

      André F. Martins, M. I. M. Prata, S. P. J. Rodrigues, Carlos F. G. C. Geraldes, P. J. Riss, A. Amor-Coarasa, C. Burchardt, C. Kroll and F. Roesch

      Version of Record online: 14 FEB 2013 | DOI: 10.1002/cmmi.1517

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      We show by spectroscopic, radiochemical, chromatographic, mass spectrometry and theoretical modelling studies that the HEPES buffer acts as a weakly but competitive chelator of Ga3+. This observation explains its superior performance relative to alternative buffer systems for 67/68Ga radiolabelling in aqueous media.

    7. Multimodal imaging of tumor response to sorafenib combined with radiation therapy: comparison between diffusion-weighted MRI, choline spectroscopy and 18F-FLT PET imaging (pages 274–280)

      Oussama Karroum, Lionel Mignion, Julie Kengen, Linda Karmani, Philippe Levêque, Pierre Danhier, Julie Magat, Anne Bol, Daniel Labar, Vincent Grégoire, Caroline Bouzin, Olivier Feron, Bernard Gallez and Bénédicte F. Jordan

      Version of Record online: 13 MAR 2013 | DOI: 10.1002/cmmi.1525

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      DW-MRI, choline 1H MRS at 11.7 T and 18F-FLT PET imaging were used to image fibrosarcoma tumor-bearing mice. The imaging markers were compared with apoptosis cell death and cell proliferation measurements assessed by histology. All imaging markers were able to show early tumor response after 2 days of treatment: choline MRS and 18F-FLT were sensitive to sorafenib in monotherapy as well as in combined therapy with irradiation, whereas DW-MRI was only sensitive to the combination of sorafenib with radiotherapy.

    8. You have full text access to this OnlineOpen article
      Evaluation of the novel USPIO GEH121333 for MR imaging of cancer immune responses (pages 281–288)

      Qiaoyun Shi, Laura J. Pisani, Yauk K. Lee, Solomon Messing, Celina Ansari, Srabani Bhaumik, Lisa Lowery, Brian D. Lee, Dan E. Meyer and Heike E. Daldrup-Link

      Version of Record online: 13 MAR 2013 | DOI: 10.1002/cmmi.1526

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      Summary of key findings: GEH121333 could be used as an imaging biomarker for TAM. This novel, dedicated MR contrast agent showed an excellent safety profile in rodents and better signal enhancement compared with the iron supplement ferumoxytol.

  4. Short Communication

    1. Top of page
    2. Issue Information
    3. Review
    4. Full Papers
    5. Short Communication
    6. Abstracts
    1. A DOTAM-based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity (pages 289–292)

      Todd K. Stevens, Mark Milne, Adam A. H. Elmehriki, Mojmír Suchý, Robert Bartha and Robert H. E. Hudson

      Version of Record online: 4 FEB 2013 | DOI: 10.1002/cmmi.1527

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      The Tm3+ chelate of DOTAM [1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane] possessing sterically demanding t-butyl amide substitution favors TSAP geometry. This chelate displays a paraCEST signal associated with the amide proton signal at approximately −100 ppm and thus escapes severe interference associated with macromolecule magnetization transfer. This paraCEST signal also displays high temperature dependence (0.57 ppm °C−1) in the range of 35–42 °C and at neutral pH.

  5. Abstracts

    1. Top of page
    2. Issue Information
    3. Review
    4. Full Papers
    5. Short Communication
    6. Abstracts

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