Optical imaging detection of microscopic mammary cancer in ErbB-2 transgenic mice through the DA364 probe binding αvβ3 integrins (pages 350–360)
Laura Conti, Stefania Lanzardo, Manuela Iezzi, Monica Montone, Elisabetta Bolli, Chiara Brioschi, Alessandro Maiocchi, Guido Forni and Federica Cavallo
Article first published online: 23 APR 2013 | DOI: 10.1002/cmmi.1529
In this paper, we demonstrate that DA364, a near-infrared fluorescence arginine–glycine–aspartic acid cyclic probe, is specifically taken up by neoplastic mammary glands of BALB/c mice transgenic for the rat ErbB-2 oncogene. This uptake increases with cancer progression and allows the optical imaging noninvasive visualization of atypical hyperplasia and microscopic foci of in situ carcinoma 2 months before they become detectable by palpation. Moreover, DA364 can be successfully used to monitor the outcome of anticancer treatments, and can thus be proposed as a promising early detection tool in the imaging of mammary cancers.