Contrast Media & Molecular Imaging

Cover image for Vol. 8 Issue 4

July/August 2013

Volume 8, Issue 4

Pages i–iii, 333–381

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Review
    4. Full Papers
    1. Issue Information (pages i–iii)

      Article first published online: 23 APR 2013 | DOI: 10.1002/cmmi.1506

  2. Review

    1. Top of page
    2. Issue Information
    3. Review
    4. Full Papers
    1. Radiolabeling approaches of nanoparticles with 99mTc (pages 333–339)

      Dimitrios Psimadas, Penelope Bouziotis, Panagiotis Georgoulias, Varvara Valotassiou, Theodoros Tsotakos and George Loudos

      Article first published online: 23 APR 2013 | DOI: 10.1002/cmmi.1530

      Thumbnail image of graphical abstract

      Nanoparticles have advantageous properties for application in various fields of medicine, e.g. drug delivery, imaging and hyperthermia. Nuclear medicine is actively involved in innovative breakthrough efforts, through the radiolabeling of nanoparticle moieties with 99mTc, which can be performed via a variety of pathways.

  3. Full Papers

    1. Top of page
    2. Issue Information
    3. Review
    4. Full Papers
    1. Regional heterogeneity changes in DCE-MRI as response to isolated limb perfusion in experimental soft-tissue sarcomas (pages 340–349)

      L. Alic, M. van Vliet, P. A. Wielopolski, T. L. M. ten Hagen, C. F. van Dijke, W. J. Niessen and J. F. Veenland

      Article first published online: 23 APR 2013 | DOI: 10.1002/cmmi.1528

      Thumbnail image of graphical abstract

      Based on DCE-MRI, the changes in tumor heterogeneity owing to isolated limb perfusion were quantified shortly after treatment. In the treated animals a significant decrease of mean Ktrans and heterogeneity could be observed, as opposed to the sham-treated animals. Heterogenic changes in regional tumor perfusion, estimated using DCE-MRI pharmacokinetic maps, can be measured and used as a noninvasive early outcome predictor in treatment monitoring and may guide therapy adaptation.

    2. Optical imaging detection of microscopic mammary cancer in ErbB-2 transgenic mice through the DA364 probe binding αvβ3 integrins (pages 350–360)

      Laura Conti, Stefania Lanzardo, Manuela Iezzi, Monica Montone, Elisabetta Bolli, Chiara Brioschi, Alessandro Maiocchi, Guido Forni and Federica Cavallo

      Article first published online: 23 APR 2013 | DOI: 10.1002/cmmi.1529

      Thumbnail image of graphical abstract

      In this paper, we demonstrate that DA364, a near-infrared fluorescence arginine–glycine–aspartic acid cyclic probe, is specifically taken up by neoplastic mammary glands of BALB/c mice transgenic for the rat ErbB-2 oncogene. This uptake increases with cancer progression and allows the optical imaging noninvasive visualization of atypical hyperplasia and microscopic foci of in situ carcinoma 2 months before they become detectable by palpation. Moreover, DA364 can be successfully used to monitor the outcome of anticancer treatments, and can thus be proposed as a promising early detection tool in the imaging of mammary cancers.

    3. Fluorometry, a fast screening technique for non-covalent binding of contrast agents to human serum albumin? (pages 361–365)

      Q. Zhou, C. Henoumont, L. Vander Elst, S. Laurent and R. N. Muller

      Article first published online: 23 APR 2013 | DOI: 10.1002/cmmi.1531

      Thumbnail image of graphical abstract

      Fluorometry is a convenient tool that can easily detect non-covalent binding of gadolinium-based MRI contrast agents with human serum albumin owing to the small amount of required compound, the simplicity of the procedure, and the popularity of the instrument. However, fluorescence screening tests should be interpreted with caution since false-negative results will occur when the binding site of a gadolinium-based agent is far away from the location of the sole Trp residue of HSA or when an unsuitable site-marker is selected.

    4. Assessment of the biodistribution of an [18F]FDG-loaded perfluorocarbon double emulsion using dynamic micro-PET in rats (pages 366–374)

      Mario L. Fabiilli, Morand R. Piert, Robert A. Koeppe, Phillip S. Sherman, Carole A. Quesada and Oliver D. Kripfgans

      Article first published online: 23 APR 2013 | DOI: 10.1002/cmmi.1532

      Thumbnail image of graphical abstract

      Perfluorocarbon (PFC) double emulsions of the form water-in-PFC-in-water (W1/PFC/W2) can carry water-soluble agents in the W1 phase, the release of which can be triggered by ultrasound in a process known as acoustic droplet vaporization. The biodistribution of [18F]fluorodeoxyglucose (FDG), encapsulated in the sonosensitive emulsion, was studied in rats using dynamic micro-PET imaging. Compared to non-emulsified FDG, less FDG uptake was observed in brain and tumor tissue with emulsified FDG, indicating stable retention of FDG within the emulsion.

    5. Erythrocytes labeled with [18F]SFB as an alternative to radioactive CO for quantification of blood volume with PET (pages 375–381)

      José Raúl Herance, Juan Domingo Gispert, Sergio Abad, Victor M. Victor, Deborah Pareto, Èlia Torrent and Santiago Rojas

      Article first published online: 23 APR 2013 | DOI: 10.1002/cmmi.1533

      Thumbnail image of graphical abstract

      Autologous red blood cells labelled with [18F]-SFB can be an alternative for blood volume PET studies avoiding the inconveniences of radioactive gas utilization. Results obtained with this method are similar than those provided by the radiolabelled CO. Additionaly, the longer half life of 18F enables its use in centers not equipped with a cyclotron.

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