Contrast Media & Molecular Imaging

Cover image for Vol. 8 Issue 5

September/October 2013

Volume 8, Issue 5

Pages i–iii, 383–421

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communication
    1. Issue Information (pages i–iii)

      Version of Record online: 6 JUN 2013 | DOI: 10.1002/cmmi.1507

  2. Full Papers

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communication
    1. Vascular changes after stroke in the rat: a longitudinal study using optimized magnetic resonance imaging (pages 383–392)

      Philipp Boehm-Sturm, Tracy D. Farr, Joanna Adamczak, Jan F. Jikeli, Luam Mengler, Dirk Wiedermann, Therése Kallur, Valerij Kiselev and Mathias Hoehn

      Version of Record online: 6 JUN 2013 | DOI: 10.1002/cmmi.1534

      Thumbnail image of graphical abstract

      We investigated the evidence of angiogenesis after transient focal ischemia in rats using SSCE MRI, which measures diffusivity of tissue and changes in transverse relaxation rates upon i.v. administration of superparamagnetic particles. Important vessel characteristics such as blood volume, vessel size and vessel density were calculated and followed up to 4 weeks after the stroke. Following stroke, vessel size increased, whereas blood volume in small vessels and vessel density decreased, indicating limited potential of ischemic tissue to form new, functional vasculature.

    2. PECAM-1-targeted micron-sized particles of iron oxide as MRI contrast agent for detection of vascular remodeling after cerebral ischemia (pages 393–401)

      Lisette H. Deddens, Geralda A. F. van Tilborg, Annette van der Toorn, Helga E. de Vries and Rick M. Dijkhuizen

      Version of Record online: 6 JUN 2013 | DOI: 10.1002/cmmi.1536

      Thumbnail image of graphical abstract

      PECAM-1, an endothelial marker that can be used for assessment of post-stroke vascular remodeling, can be effectively targeted in vitro with MPIO conjugated with PECAM-1 antibody, giving rise to significant contrast enhancement on MR images. Nevertheless, application of this targeted contrast agent was ineffective for in vivo molecular MRI of angiogenesis at 3 or 7 days after experimental stroke in mice, which may be explained by inefficient binding of the large multivalent ligand-presenting construct under in vivo conditions.

    3. Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice (pages 402–408)

      Linda Karmani, Daniel Labar, Vanessa Valembois, Virginie Bouchat, Praveen Ganesh Nagaswaran, Anne Bol, Jacques Gillart, Philippe Levêque, Caroline Bouzin, Davide Bonifazi, Carine Michiels, Olivier Feron, Vincent Grégoire, Stéphane Lucas, Thierry Vander Borght and Bernard Gallez

      Version of Record online: 6 JUN 2013 | DOI: 10.1002/cmmi.1539

      Thumbnail image of graphical abstract

      Two tracers 89Zr-labeled cetuximab (89Zr-Df-Bz-NCS-cetuximab) and 89Zr-cetuximab conjugated to gold nanoparticles (AuNPs-PPAA-cetuximab-89Zr) were injected in A431 xenograft-bearing mice and their biodistribution was studied using quantitative PET imaging. Radioimmunoconjugates were carefully characterized before injection. Immuno-PET studies revealed no significant difference in tumor uptake for AuNPs-PPAA-cetuximab-89Zr up to 72 h after injection, compared with 89Zr-Df-Bz-NCS-cetuximab and showed a maintaining of high tumor contrast. However, the liver uptake of AuNPs-PPAA-cetuximab-89Zr was higher. In vivo blocking experiments demonstrated selective tumor targeting after coupling reaction.

    4. [18F]-FBEM, a tracer targeting cell-surface protein thiols for cell trafficking imaging (pages 409–416)

      Simon Lacroix, Dominique Egrise, Gaetan Van Simaeys, Gilles Doumont, M. Monclus, F. Sherer, T. Herbaux, D. Leroy and Serge Goldman

      Version of Record online: 6 JUN 2013 | DOI: 10.1002/cmmi.1540

      Thumbnail image of graphical abstract

      Direct cell-surface radiolabelling with fluorine-18 through thiol-maleimide reaction allowed T lymphocyte trafficking imaging in vivo using PET.

  3. Short Communication

    1. Top of page
    2. Issue Information
    3. Full Papers
    4. Short Communication
    1. 15N-Permethylated amino acids as efficient probes for MRI-DNP applications (pages 417–421)

      Enrico Chiavazza, Alessandra Viale, Magnus Karlsson and Silvio Aime

      Version of Record online: 6 JUN 2013 | DOI: 10.1002/cmmi.1538

      Thumbnail image of graphical abstract

      15N-permethylated, perdeuterated amino acids display very long-T1 values for the (CD3)3 15N resonances thus representing particularly suitable substrates for applications such as perfusion or targeting studies.

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