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Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma
Implications for clinical trials in this patient population
Article first published online: 4 APR 2002
DOI: 10.1002/cncr.0680
Copyright © 2002 American Cancer Society
Additional Information
How to Cite
Perkins, J. G., Flynn, J. M., Howard, R. S. and Byrd, J. C. (2002), Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma. Cancer, 94: 2033–2039. doi: 10.1002/cncr.0680
Publication History
- Issue published online: 4 APR 2002
- Article first published online: 4 APR 2002
- Manuscript Accepted: 13 DEC 2001
- Manuscript Revised: 5 JUL 2001
- Manuscript Received: 28 DEC 2000
Funded by
- Chronic Lymphocytic Leukemia Research Consortium. Grant Number: P01 CA81534-02
- Sidney Kimmel Cancer Research Foundation
REFERENCES
- 1, , , et al. Chronic leukemias. In: DeVitaVT, JellmanS, RosenbergSA, editors. Cancer, principles and practice of oncology. 5th ed. Philadelphia: JB Lippincott Company, 1997: 2321–2326.
- 2, . Current concepts: chronic lymphocytic leukemia. N Engl J Med. 1995; 336: 1052–1057.
- 3, , , et al. Presenting features and prognosis of chronic lymphocytic leukemia in younger adults. Blood. 1991; 78: 1545–1551.
- 4, , , . Randomized comparison of fludarabine, CAP, and CHOP in 695 previously untreated stage B and C chronic lymphocytic leukemia(CLL). Early stopping of the CAP accrual [abstract]. Blood. 1997; 90: 529.
- 5, , , et al. A randomized comparison of fludarabine and chlorambucil for patients with previously untreated chronic lymphocytic leukemia. A CALGB, SWOG, CTG/NCI-C, and ECOG Inter-group study [abstract]. Blood. 1996; 88: 141.
- 6, , , et al. Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. The French Cooperative Group on CLL. Lancet. 1996; 347: 1432–1438.
- 7, , , et al. Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. N Engl J Med. 1998; 338: 1506–1514.
- 8, , , , . Treatment of refractory chronic lymphocytic leukemia with fludarabine phosphate via the group C protocol mechanism of the National Cancer Institute: five-year follow-up report. J Clin Oncol. 1997; 15: 458–465.
- 9, , , , . Fludarabine and prednisone in pretreated and refractory B-chronic lymphocytic leukemia (B-CLL) in advanced stages. Haematologica. 1993; 78: 167–171.
- 10, , , et al. Fludarabine treatment in B-cell chronic lymphocytic leukemia: response, toxicity and survival analysis in 47 cases. Haematologica. 1999; 84: 317–323.
- 11, , , et al. Fludarabine in patients with advanced and/or resistant B-chronic lymphocytic leukemia. Eur J Haematol. 1993; 51: 93–97.Direct Link:
- 12, , , et al. Fludarabine in untreated and previously treated B-CLL patients: a report on efficacy and toxicity. Haematologica. 1994; 79: 218–224.
- 13, , , et al. Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy. Blood. 1998; 92: 1165–1171.
- 14, , , et al. Fludarabine in resistant or relapsing B-cell chronic lymphocytic leukemia: the Spanish Group experience. Leuk Lymphoma. 1996; 21: 467–472.
- 15, , , . Old and new therapies in chronic lymphocytic leukemia: now is the time for a reassessment of therapeutic goals. Semin Oncol. 1998; 25: 65–74.
- 16, , , , . Early safety and efficacy results using Campath-1H (CP-1H), a humanized antilymphocyte monoclonal antibody (MAB), in non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL) [abstract]. Proc Annu Meet Am Soc Clin Oncol. 1993; 12: A1286.
- 17, , , , , . Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia. Br J Haematol. 1997; 96: 617–619.Direct Link:
- 18
- 19, , , et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol. 1997; 15: 1567–1574.
- 20, , . National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996; 87: 4990–4997.
- 21, , . Rituximab monoclonal antibody as initial systemic therapy for patients with low-grade non-Hodgkin lymphoma. Blood. 2000; 95: 3052–3056.
- 22, , , et al. Multicenter study of Campath-1H in patients with chronic lymphocytic leukemia (B-CLL) refractory to fludarabine, Campath-1H collaborative study group [abstract]. Blood. 1999; 94 (Suppl 1): 3118.
- 23, , , et al. Infections in patients with chronic lymphocytic leukemia treated with fludarabine. Ann Intern Med. 1998; 129: 559–566.
- 24, , . Infectious complications in chronic lymphocytic leukaemia. Hematol Cell Ther. 1999; 41: 145–151.
- 25, , , . Severe pneumococcal infection in patients with neoplastic disease. Cancer. 1983; 51: 1546–1550.Direct Link:
- 26
- 27, , , , . Severe infections associated with chronic lymphoid leukemia. 159 infectious episodes in 60 patients. Presse Med. 1986; 15: 1715–1718.
- 28. Viral warts, herpes simplex, and herpes zoster in patients with secondary immune deficiencies and neoplasms. Br J Dermatol. 1975; 92: 625–630.Direct Link:
- 29, , , , , . Herpes virus infections occur frequently following treatment with fludarabine: results of a prospective natural history study. Br J Haematol. 1999; 105: 445–447.Direct Link:
- 30, , . Opportunistic infections in patients with chronic lymphocytic leukemia following treatment with fludarabine. Am J Hematol. 1992; 39: 314–315.Direct Link:
- 31, , , et al. Clinical experience with fludarabine and its immunosuppressive effects in pretreated chronic lymphocytic leukemias and low-grade lymphomas. Leuk Lymphoma. 1995; 18: 485–492.

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