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The American Cancer Society Cancer Prevention Study II Nutrition Cohort †
Rationale, study design, and baseline characteristics
Article first published online: 25 APR 2002
Copyright © 2002 American Cancer Society
Volume 94, Issue 9, pages 2490–2501, 1 May 2002
How to Cite
Calle, E. E., Rodriguez, C., Jacobs, E. J., Almon, M. L., Chao, A., McCullough, M. L., Feigelson, H. S. and Thun, M. J. (2002), The American Cancer Society Cancer Prevention Study II Nutrition Cohort . Cancer, 94: 2490–2501. doi: 10.1002/cncr.101970
This article was previously published (Cancer 2002;94:500–511); the earlier published version did not reflect key edits which were necessary in light of the authors' decision about when to terminate the follow-up of the cohort. Readers are asked to consider this reprinted version of the article to be the official citation.
- Issue published online: 25 APR 2002
- Article first published online: 25 APR 2002
- Manuscript Accepted: 11 SEP 2001
- Manuscript Revised: 7 SEP 2001
- Manuscript Received: 7 JUN 2001
- cohort studies;
- physical fitness;
- prospective studies;
Large-scale, prospective cohort studies have played a critical role in discovering factors that contribute to variability in cancer risk in human populations. Epidemiologists and volunteers at the American Cancer Society (ACS) were among the first to establish such cohorts, beginning in the early 1950s and continuing through the present, and these ACS cohorts have made landmark contributions in many areas of epidemiologic research.
METHODS AND RESULTS
The Cancer Prevention Study II Nutrition Cohort was established in 1992 and was designed to investigate the relation between diet and other lifestyle factors and exposures and the risk of cancer, mortality, and survival. The cohort includes over 84,000 men and 97,000 women who completed a mailed questionnaire in 1992. New questionnaires are sent to surviving cohort members every other year to update exposure information and to ascertain new occurrences of cancer; a 90% response rate was achieved for follow-up questionnaires in 1997 and 1999. Reported cancers are verified through medical records, registry linkage, or death certificates. The cohort is followed actively for all cases of incident cancer and for all causes of death. Through a collaborative effort among ACS national and division staff, volunteers, and the American College of Surgeons, blood samples were collected from a subgroup of 40,000 cohort members and are in storage at a central repository for future investigation of dietary, hormonal, genetic, and other factors and cancer risk. Collection of DNA samples from buccal cells in an additional 50,000 cohort members is underway currently and will be completed in 2002.
This new cohort of both men and women promises to be particularly valuable for the study of cancer occurrence, mortality, and survival as they relate to obesity and weight change, physical activity at various points in life, vitamin supplement use, exogenous hormone use, other medications (such as aspirin and nonsteroidal anti- inflammatory drugs) and cancer screening modalities. Cancer 2002;94:2490–2501. © 2002 American Cancer Society.