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Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

  1. Kentaro Kato M.D.1,†,*,
  2. Yasuhiro Hida M.D.1,
  3. Masaki Miyamoto M.D.1,
  4. Hideaki Hashida M.D.1,
  5. Toshiya Shinohara M.D.2,
  6. Tomoo Itoh M.D.3,
  7. Shunichi Okushiba M.D.1,
  8. Satoshi Kondo M.D.1,
  9. Hiroyuki Katoh Ph.D.1

Article first published online: 20 FEB 2002

DOI: 10.1002/cncr.10329

Issue

Cancer

Cancer

Volume 94, Issue 4, pages 929–933, 15 February 2002

Additional Information

How to Cite

Kato, K., Hida, Y., Miyamoto, M., Hashida, H., Shinohara, T., Itoh, T., Okushiba, S., Kondo, S. and Katoh, H. (2002), Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer, 94: 929–933. doi: 10.1002/cncr.10329

Author Information

  1. 1

    Department of Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate school of Medicine, Sapporo, Japan

  2. 2

    Department of Pathology, Teine Keijinkai Hospital, Sapporo, Japan

  3. 3

    Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan

  1. †

    Fax: 011 81-011-706-7158

*Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan

  1. †

    Fax: 011 81-011-706-7158

Publication History

  1. Issue published online: 20 FEB 2002
  2. Article first published online: 20 FEB 2002
  3. Manuscript Accepted: 18 OCT 2001
  4. Manuscript Revised: 15 OCT 2001
  5. Manuscript Received: 17 MAY 2001

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Keywords:

  • caveolin-1;
  • esophageal carcinoma;
  • lymph node metastasis;
  • prognosis

Abstract

BACKGROUND

Caveolin-1 plays a regulatory role in several signaling pathways. Recently caveolin-1 was identified as a metastasis-related gene in prostate carcinoma. However, the clinical impact of caveolin-1 expression in esophageal carcinoma remains unknown.

METHODS

One hundred thirty surgical specimens of esophageal squamous cell carcinoma were immunohistochemically assessed for caveolin-1 expression by polyclonal antibody. Caveolin-1 immunoreactivity was correlated with patients' clinicopathologic parameters and outcome.

RESULTS

Positive caveolin-1 immunostaining was detected in 58 patients (44.6%). Positive caveolin-1 immunostaining correlated positively with pathologic stage (P = 0.029), pN (P = 0.023), and pM (P = 0.018). The overall survival rate was worse in patients with caveolin-1-positive tumors than in patients with caveolin-1-negative tumors (P = 0.0215). Univariate analyses identified caveolin-1 positivity (P = 0.0238), pT (P = 0.0002), pN (P < 0.0001), pM (P = 0.0002), lymphatic invasion (P = 0.0021), and positive surgical margin (P < 0.0001) as negative prognostic predictors. Multivariate analyses indicated that pT (P = 0.0296), pN (P = 0.0003), and a positive surgical margin (P = 0.0452) were independent prognostic factors.

CONCLUSIONS

Over-expression of caveolin-1 is associated with lymph node metastasis and a worse prognosis after surgery in esophageal squamous cell carcinoma. Cancer 2002;94:929–33. © 2002 American Cancer Society.

DOI 10.1002/cncr.10329

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