Stella M. Ranuncolo, Elisa Bal de Kier Joffe, and Lydia Puricelli are members of the National Council of Scientific and Technical Research (CONICET).
Circulating 92-kilodalton matrix metalloproteinase (MMP-9) activity is enhanced in the euglobulin plasma fraction of head and neck squamous cell carcinoma
Article first published online: 11 MAR 2002
Copyright © 2002 American Cancer Society
Volume 94, Issue 5, pages 1483–1491, 1 March 2002
How to Cite
Ranuncolo, S. M., Matos, E., Loria, D., Vilensky, M., Rojo, R., Bal de Kier Joffé, E. and Inés Puricelli, L. (2002), Circulating 92-kilodalton matrix metalloproteinase (MMP-9) activity is enhanced in the euglobulin plasma fraction of head and neck squamous cell carcinoma. Cancer, 94: 1483–1491. doi: 10.1002/cncr.10356
- Issue published online: 11 MAR 2002
- Article first published online: 11 MAR 2002
- Manuscript Accepted: 12 NOV 2001
- Manuscript Revised: 4 OCT 2001
- Manuscript Received: 2 OCT 2001
- SECYT: Pré stamo Bid. Grant Numbers: 1201/OC-AR PICT 4926, PICT 4765
- circulating 92-kilodalton (kDa) matrix metalloproteinase (MMP);
- tumor marker;
- laryngeal carcinoma;
- oropharyngeal carcinoma
Cancer lethality is usually the result of local invasion and metastasis of neoplastic cells from the primary tumor. Because of their ability to degrade extracellular matrix components (EMC), matrix metalloproteinases (MMPs) have been implicated in the breakdown of basement membranes and underlying stroma, thereby facilitating tumor growth and invasion.
The authors quantitated, by gelatin zymography and densitometric analysis, MMP activity in the euglobulin plasma fraction of 50 healthy controls and 91 head and neck squamous cell carcinoma (HNSCC) patients (51 from the larynx and 40 from the oropharynx).
The median value for 92-kilodalton (kD) MMP (MMP-9) activity was increased significantly in laryngeal (Md 2.1 arbitrary units (AU)/mL plasma; range, 0.2–6.4) and oropharyngeal patients (Md 2.08 AU/mL; range, 0.0–5.0) with respect to the controls (Md 0.48 AU/mL; range, 0.0–1.8). Both groups of cancer patients showed a similar behavior. Multivariate analysis indicated that circulating 92-kD MMP activity was not predicted by the clinical-pathologic parameters such as tumor stage, histologic grade, and metastatic lymph nodes. There was no association between high levels of MMP-9 activity and either cigarette smoking or alcohol consumption, major risk factors for developing HNSCC.
The authors found a significant increase of MMP-9 plasma activity both in laryngeal and oropharyngeal squamous cell carcinoma patients as compared with healthy controls. Further studies are necessary to establish its usefulness in the clinical management of these patients. Cancer 2002;94:1483–91. © 2002 American Cancer Society.