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The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma

  1. Isis Dove-Edwin1,
  2. Dominique Boks M.D.2,
  3. Sheila Goff M.Sc.1,
  4. Gemma G. Kenter Ph.D.3,
  5. Robert Carpenter4,
  6. Hans F. A. Vasen Ph.D.3,
  7. Huw J. W. Thomas Ph.D.1,†,*

Article first published online: 15 MAR 2002

DOI: 10.1002/cncr.10380

Issue

Cancer

Cancer

Volume 94, Issue 6, pages 1708–1712, 15 March 2002

Additional Information

How to Cite

Dove-Edwin, I., Boks, D., Goff, S., Kenter, G. G., Carpenter, R., Vasen, H. F. A. and Thomas, H. J. W. (2002), The outcome of endometrial carcinoma surveillance by ultrasound scan in women at risk of hereditary nonpolyposis colorectal carcinoma and familial colorectal carcinoma. Cancer, 94: 1708–1712. doi: 10.1002/cncr.10380

Author Information

  1. 1

    Imperial Cancer Research Fund Family Cancer Clinic, St Mark's Hospital, London, UK

  2. 2

    Department of Gynecology, Leiden University Medical Centre, Leiden, The Netherlands

  3. 3

    The Netherlands Foundation for the Detection of Hereditary Tumours: Campus Leiden University Medical Centre, Leiden, The Netherlands

  4. 4

    Breast and Endocrine Unit, St Bartholomew's Hospital, London, UK

  1. †

    Fax: (011) +44 20 8235 4277

*Imperial Cancer Research Fund Family Cancer Clinic, St Mark's Hospital, Watford Road, Harrow, Middlesex UK

Publication History

  1. Issue published online: 15 MAR 2002
  2. Article first published online: 15 MAR 2002
  3. Manuscript Accepted: 30 NOV 2001
  4. Manuscript Revised: 26 NOV 2001
  5. Manuscript Received: 6 NOV 2000

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Keywords:

  • hereditary nonpolyposis colorectal carcinoma syndrome;
  • endometrial carcinoma;
  • surveillance;
  • transvaginal ultrasound

Endometrial carcinoma surveillance by ultrasound scanning was offered to women from hereditary nonpolyposis colorectal carcinoma syndrome (HNPCC) and HNPCC-like families. The cases of endometrial carcinoma which occurred presented with symptoms and were not detected by surveillance.

Abstract

BACKGROUND

Endometrial carcinoma is the most common extracolonic malignancy associated with hereditary nonpolyposis colorectal carcinoma syndrome (HNPCC). The risk of endometrial carcinoma in HNPCC mutation carriers is approximately ten times that of the general population, and endometrial ultrasound surveillance to detect early cancer in asymptomatic individuals is recommended by the International Collaborative Group on HNPCC. There is little, if any, published data addressing the effectiveness of surveillance in HNPCC and familial colorectal carcinoma.

METHODS

The outcomes of endometrial carcinoma surveillance scans were collected from the St Mark's Hospital Imperial Cancer Research Fund Family Cancer Clinic in the UK and the Netherlands Foundation for the Detection of Hereditary Tumors. Two hundred ninety two women from HNPCC (171) or HNPCC-like (98) families between the ages of 25-65 years were offered pelvic ultrasound surveillance scans for a period of up to 13 years.

RESULTS

Results were available from 269 women. The study period included a total of 825.7 years of risk. Two cases of endometrial carcinoma were reported. Neither case was detected by surveillance scanning. Both cases presented at an early stage with symptoms and were subsequently cured.

CONCLUSIONS

Endometrial carcinoma surveillance in hereditary colorectal carcinoma may not offer obvious clinical benefits. Cancer 2002;94:1708–12. © 2002 American Cancer Society.

DOI 10.1002/cncr.10380

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