The prevalence of high-grade prostatic intraepithelial neoplasia in surgical resection specimens

An Indian experience

Authors


Abstract

BACKGROUND

To the authors' knowledge there is a paucity of literature regarding the prevalence of high-grade prostatic intraepithelial neoplasia (HGPIN) in the Indian subcontinent. The objective of the current study was to document the prevalence of HGPIN in a low-risk Indian population.

METHODS

A total of 110 prostate specimens (61 taken from the test group and 49 taken from the control group) were studied to document the prevalence of HGPIN in a low-risk Indian population.

RESULTS

None of the benign prostate samples were found to harbor HGPIN, whereas 85.24% of the samples from malignant prostates did so.

CONCLUSIONS

A strong correlation between HGPIN and invasive carcinoma was observed, a finding that reinforces the view that HGPIN is a strong indicator of concurrent invasive prostate carcinoma. Cancer 2002;94:2350–2. © 2002 American Cancer Society.

DOI 10.1002/cncr.10495

Ancillary