Original Article

You have full text access to this OnlineOpen article

Motor nervous system impairment persists in long-term survivors of childhood acute lymphoblastic leukemia

  1. Satu S. Lehtinen M.D.1,†,*,
  2. Usko E. Huuskonen M.D.2,
  3. Arja H. Harila-Saari M.D., Ph.D.1,
  4. Uolevi Tolonen M.D., Ph.D.2,
  5. Leena K. Vainionpää M.D., Ph.D.1,
  6. B. Marjatta Lanning M.D., Ph.D.1

Article first published online: 25 APR 2002

DOI: 10.1002/cncr.10503

Issue

Cancer

Cancer

Volume 94, Issue 9, pages 2466–2473, 1 May 2002

Additional Information

How to Cite

Lehtinen, S. S., Huuskonen, U. E., Harila-Saari, A. H., Tolonen, U., Vainionpää, L. K. and Lanning, B. M. (2002), Motor nervous system impairment persists in long-term survivors of childhood acute lymphoblastic leukemia. Cancer, 94: 2466–2473. doi: 10.1002/cncr.10503

Author Information

  1. 1

    Department of Pediatrics, Oulu University Central Hospital, Oulu, Finland

  2. 2

    Department of Clinical Neurophysiology, Oulu University Central Hospital, Oulu, Finland

  1. †

    Fax: (011) + 358-8-315 5559

*Department of Pediatrics, PL 5000, 90014 Oulun yliopisto, Finland

  1. †

    Fax: (011) + 358-8-315 5559

Publication History

  1. Issue published online: 25 APR 2002
  2. Article first published online: 25 APR 2002
  3. Manuscript Accepted: 20 DEC 2001
  4. Manuscript Revised: 18 DEC 2001
  5. Manuscript Received: 17 SEP 2001

Funded by

  • Alma och K. A. Snellman Foundation
  • Nona and Kullervo Väre Foundation, Helsinki, Finland

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (80K)

REFERENCES

  • 1
    Ochs JJ. Neurotoxicity due to central nervous system therapy for childhood leukemia. Am J Pediatr Hematol Oncol. 1989; 11: 93–105.
  • 2
    Wilson DA, Nitschke R, Bowman ME, Chaffin MJ, Sexauer CL, Prince JR. Transient white matter changes on MR images in children undergoing chemotherapy for acute lymphocytic leukemia: correlation with neuropsychologic deficiencies. Radiology. 1991; 180: 205–209.
  • 3
    Pääkkö E, Vainionpää L, Lanning M, Laitinen J, Pyhtinen J. White matter changes in children treated for acute lymphoblastic leukemia. Cancer. 1992; 70: 2728–2733.
    Direct Link:
  • 4
    Watterson J, Toogood I, Nieder M, et al. Excessive spinal cord toxicity from intensive central nervous system-directed therapies. Cancer. 1994; 74: 3034–3041.
    Direct Link:
  • 5
    Casey EB, Jellife AM, Le Quesne PM, Millett YL. Vincristine neuropathy. Clinical and electrophysiological observations. Brain. 1973; 96: 69–86.
  • 6
    Harila-Saari AH, Vainionpää LK, Kovala TT, Tolonen EU, Lanning BM. Nerve lesions after therapy for childhood acute lymphoblastic leukemia. Cancer. 1998; 82: 200–207.
    Direct Link:
  • 7
    Sandler SG, Tobin W, Henderson ES. Vincristine-induced neuropathy. A clinical study of fifty leukemic patients. Neurology. 1969; 19: 367–374.
  • 8
    Vainionpää L, Kovala T, Tolonen U, Lanning M. Vincristine therapy for children with acute lymphoblastic leukemia impairs conduction in the entire peripheral nerve. Pediatr Neurol. 1995; 13: 314–318.
  • 9
    Reinders-Messelink HA, Schoemaker MM, Hofte M, et al. Fine motor and handwriting problems after treatment for childhood acute lymphoblastic leukemia. Med Pediatr Oncol. 1996; 27: 551–555.
    Direct Link:
  • 10
    Vainionpää L. Clinical neurological findings of children with acute lymphoblastic leukaemia at diagnosis and during treatment. Eur J Pediatr. 1993; 152: 115–119.
  • 11
    Harila-Saari AH, Huuskonen UE, Tolonen U, Vainionpaa LK, Lanning BM. Motor nervous pathway function is impaired after treatment of childhood acute lymphoblastic leukemia: a study with motor evoked potentials. Med Pediatr Oncol. 2001; 36: 345–351.
    Direct Link:
  • 12
    Gustafsson G, Garwicz S, Hertz H, et al. A population-based study of childhood acute lymphoblastic leukemia diagnosed from July 1981 through June 1985 in the five Nordic countries. Incidence, patient characteristics and treatment results. Acta Paediatr Scand. 1987; 76: 781–788.
    Direct Link:
  • 13
    Gustafsson G, Berglund G, Garwicz S, et al. A population-based study of children with standard risk acute lymphoblastic leukemia in the five Nordic countries. A follow-up of 230 patients. Acta Paediatr Scand. 1989; 78: 104–109.
    Direct Link:
  • 14
    Riehm H, Reiter A, Schrappe M, et al. [Corticosteroid-dependent reduction of leukocyte count in blood as a prognostic factor in acute lymphoblastic leukemia in childhood (therapy study ALL-BFM 83)]. Klin Padiatr. 1987; 199: 151–160.
  • 15
    Touwen BCL. Examination of the child with minor neurological dysfunction. Clinics in developmental medicine. No 71. 2nd edition. London: Heinemann Medical, 1979.
  • 16
    Maegaki Y, Inagaki M, Takeshita K. Cervical magnetic stimulation in children and adolescents: normal values and evaluation of the proximal lesion of the peripheral motor nerve in cases with polyradiculoneuropathy. Electroencephalogr Clin Neurophysiol. 1994; 93: 318–323.
  • 17
    Di Lazzoro,V, Oliviero A, Profice P, et al. The diagnostic value of motor evoked potentials. Clin Neurophysiol. 1999; 110: 1297–1307.
  • 18
    Cho ES, Lowndes HE, Goldstein BD. Neurotoxicology of vincristine in the cat. Morphological study. Arch Toxicol. 1983; 52: 83–90.
  • 19
    Vainionpää L, Kovala T, Tolonen U, Lanning M. Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials. Med Pediatr Oncol. 1997; 28: 41–47.
    Direct Link:
  • 20
    Asato R, Akiyama Y, Ito M, et al. Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate. Cancer. 1992; 70: 1997–2004.
    Direct Link:
  • 21
    Van der Knaap MS, Valk J. Leukoencephalopathy after chemotherapy and/or radiotherapy. In: Magnetic resonance of myelin, myelination and myelin disorders. 2nd edition. Heidelberg: Springer-Verlag, 1995: 10–11, 408.
  • 22
    Pääkkö E, Harila-Saari A, Vainionpää L, Himanen S, Pyhtinen J, Lanning M. White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings. Med Pediatr Oncol. 2000; 35: 456–461.
    Direct Link:
  • 23
    Russo A, Tomarchio S, Pero G, et al. Abnormal visual-evoked potentials in leukemic children after cranial radiation. Med Pediatr Oncol. 1985; 13: 313–317.
    Direct Link:
  • 24
    Russo A, Schiliro G. Some aspects of neurotoxicity associated with central nervous system prophylaxis in childhood leukemia. Acta Haematol. 1987; 78( Suppl 1): 139–141.
  • 25
    Laitt RD, Chambers EJ, Goddard PR, Wakeley CJ, Duncan AW, Foreman NK. Magnetic resonance imaging and magnetic resonance angiography in long term survivors of acute lymphoblastic leukemia treated with cranial irradiation. Cancer. 1995; 76: 1846–1852.
    Direct Link:
  • 26
    Ochs J, Mulhern R, Fairclough D, et al. Comparison of neuropsychologic functioning and clinical indicators of neurotoxicity on long-term survivors of childhood leukemia given cranial radiation or parental methotrexate: a prospective study. J Clin Oncol. 1991; 9: 145–151.
  • 27
    Brown RT, Madan-Swain A, Pais R, Lambert RG, Sexson S, Ragab A. Chemotherapy for acute lymphocytic leukemia: cognitive and academic sequelae. J Pediatr. 1992; 121: 885–889.
  • 28
    Espy KA, Moore IM, Kaufmann PM, Kramer JH, Matthay K, Hutter JJ. Chemotherapeutic CNS prophylaxis and neuropsychologic change in children with acute lymphoblastic leukemia: a prospective study. J Pediatr Psychol. 2001; 26: 1–9.
  • 29
    Ellaway PH, Davey NJ, Maskill DW, Rawlinson SR, Lewis HS, Anissimova NP. Variability in the amplitude of skeletal muscle responses to magnetic stimulation of the motor cortex in man. Electroencephalogr Clin Neurophysiol. 1998; 109: 104–113.
View Full Article (HTML) Get PDF (80K)