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A natural history of melanomas and dysplastic nevi
An atlas of lesions in melanoma-prone families
Article first published online: 12 JUN 2002
Copyright © 2002 American Cancer Society
Volume 94, Issue 12, pages 3192–3209, 15 June 2002
How to Cite
Tucker, M. A., Fraser, M. C., Goldstein, A. M., Struewing, J. P., King, M. A., Crawford, J. T., Chiazze, E. A., Zametkin, D. P., Fontaine, L. S. and Clark, W. H. (2002), A natural history of melanomas and dysplastic nevi. Cancer, 94: 3192–3209. doi: 10.1002/cncr.10605
- Issue published online: 12 JUN 2002
- Article first published online: 12 JUN 2002
- Manuscript Accepted: 29 JAN 2002
- Manuscript Revised: 25 JAN 2002
- Manuscript Received: 8 NOV 2001
- intramural National Cancer Institute funds
- dysplastic nevi;
- familial melanoma
Few long-term clinical and histologic data for melanocytic lesions have been available based on the mutation status of families at an increased risk of melanoma. In the current study, the authors describe the clinical and histologic features of dysplastic nevi and melanoma over time in families at an increased risk of melanoma with differing germline mutations in CDKN2A, CDK4, or not yet identified genes.
Thirty-three families with > 2 living members with invasive melanoma were evaluated clinically and followed prospectively for up to 25 years. All the participants were evaluated by the same study team at the Clinical Center of the National Institutes of Health or in local clinics. After informed consent was obtained, family members (n = 844) were examined and photographed. Blood was obtained for genetic studies; genotyping for CDKN2A and CDK4 was performed. Sequential photographs of melanocytic lesions were taken as part of the clinical evaluations. When melanocytic lesions were removed, the histology was reviewed. Representative photographs and photomicrographs were selected for six classes of lesions and three mutation groups.
All the families were found to have members with dysplastic nevi and melanoma; 17 had mutations in CDKN2A, 2 had mutations in CDK4, and 14 had no mutations in either gene identified. The majority of dysplastic nevi either remain stable or regress; few change in a manner that should cause concern for melanoma. With careful surveillance, melanomas can be found early.
The melanomas and dysplastic nevi that were found to occur in the study families did not appear to vary by the type of mutation identified in the families. Cancer 2002;94:3192–209. © 2002 American Cancer Society.