1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470 "Cancer")
Fax: 011 (+81)-11-614-0860
1097-0142/asset/olbannerleft.gif?v=1&s=ca681f5719430b26e1bc15e9ea4c9fc0a7110104)
1097-0142/asset/olbannerright.gif?v=1&s=8142566facf7e76aef9be6c51162a2e920b3b9f9)
Original Article
You have full text access to this OnlineOpen article
Hypermethylation in promoter region of E-cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma
Article first published online: 3 FEB 2003
DOI: 10.1002/cncr.11157
Copyright © 2003 American Cancer Society
Additional Information
How to Cite
Saito, T., Nishimura, M., Yamasaki, H. and Kudo, R. (2003), Hypermethylation in promoter region of E-cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma. Cancer, 97: 1002–1009. doi: 10.1002/cncr.11157
- †
Fax: 011 (+81)-11-614-0860
Publication History
- Issue published online: 3 FEB 2003
- Article first published online: 3 FEB 2003
- Manuscript Accepted: 25 SEP 2002
- Manuscript Revised: 8 AUG 2002
- Manuscript Received: 17 JUN 2002
Funded by
- Ministry of Education, Culture, Sports, Science and Technology of Japan
REFERENCES
- 1. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 1991; 251: 1451–1455.
- 2, , , . Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol. 1989; 108: 2435–2447.
- 3, , , , . Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 1991; 66: 107–119.
- 4, , , et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol. 1991; 113: 173–185.
- 5, , , et al. Decreased E-cadherin expression in endometrial carcinoma is associated with tumor dedifferentiation and deep myometrial invasion. Gynecol Oncol. 1994; 53: 183–189.
- 6, . Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. Cancer Lett. 1991; 57: 131–135.
- 7, . Expression of E- and P-cadherin in gastric carcinomas. Cancer Res. 1991; 51: 2185–2192.
- 8, , , , , . E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res. 1991; 51: 6328–6337.
- 9, , , et al. Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol. 1991; 139: 17–23.
- 10, , , et al. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol. 1993; 142: 987–993.
- 11, , . Role for DNA methylation in genomic imprinting. Nature. 1993; 366: 362–365.
- 12, . The cellular basis of tumor progression. Int Rev Cytol. 1998; 177: 1–56.
- 13, , , , . Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res. 1998; 72: 141–196.
- 14, . Cancer epigenetics comes of age. Nat Genet. 1999; 21: 163–167.
- 15, , , et al. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res. 1995; 55: 5195–5199.
- 16, , . Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas. Clin Cancer Res. 2001; 7: 594–599.
- 17. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol. 1998; 153: 333–339.
- 18, , , , . Assessment of hypermethylated DNA in two promoter regions of the estrogen receptor alpha gene in human endometrial diseases. Gynecol Oncol. 2000; 76: 89–96.
- 19, , , , . Cytosine-phosphoguanine methylation of estrogen receptors in endometrial cancer. Cancer Res. 2001; 61: 3262–3266.
- 20, , , , , . Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer. Cancer Res. 2001; 61: 97–102.
- 21, , , , , . Induction of cell transformation by mutated 16K vacuolar H+-atpase (ductin) is accompanied by down-regulation of gap junctional intercellular communication and translocation of connexin 43 in NIH3T3 cells. Oncogene. 1998; 17: 1673–1680.
- 22, , , , . Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A. 1996; 93: 9821–9826.
- 23, , , , , . Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci U S A. 1995; 92: 7416–7419.
- 24. DNA methylation errors and cancer. Cancer Res. 1996; 56: 2463–2467.
- 25, , , , . Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer. 2002; 94: 386–392.
- 26, , , et al. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clin Cancer Res. 2002; 8: 464–470.
- 27, , , et al. Decreased expression of catenins (alpha and beta), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas. Cancer. 2001; 92: 2786–2795.
- 28, , , , , . The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas. Int J Cancer. 2001; 93: 667–673.
- 29, , , et al. Methylation of the E-cadherin gene promoter correlates with progression of prostate cancer. J Urol. 2001; 166: 705–709.
- 30, , , et al. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst. 2000; 92: 569–573.
- 31, , . Carcinoma of the endometrium. II. Papillary adenocarcinoma: a clinical pathological study, 46 cases. Am J Clin Pathol. 1982; 77: 534–540.
- 32, , , et al. Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A Gynecologic Oncology Group pathologic study of 203 cases. Int J Gynecol Pathol. 1990; 9: 1–19.
- 33, , , . Endometrial cancer chemoprevention: implications of diverse pathways of carcinogenesis. J Cell Biochem. Suppl. 1995; 23: 160–164.Direct Link:
- 34, , . Uncoupling cadherin-based adhesion from wingless signalling in Drosophila. Nature. 1996; 383: 627–630.
- 35, . Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta. 1994; 1198: 11–26.
- 36, , , , , . Nuclear localization of beta-catenin in normal and carcinogenic endometrium. Mol Carcinog. 1999; 25: 207–218.
- 37
- 38, , , et al. Loss of gamma-catenin expression in squamous differentiation in endometrial carcinomas. Int J Gynecol Pathol. 2002; 21: 246–254.